Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 855136..855675 Replicon chromosome
Accession NZ_CP071138
Organism Mammaliicoccus sciuri strain SSC-7107

Toxin (Protein)


Gene name mazF Uniprot ID A0A418JBZ2
Locus tag JTZ62_RS04145 Protein ID WP_048540867.1
Coordinates 855304..855675 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A657XHG2
Locus tag JTZ62_RS04140 Protein ID WP_025904510.1
Coordinates 855136..855303 (+) Length 56 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JTZ62_RS04115 851018..851497 + 480 WP_058612364.1 PH domain-containing protein -
JTZ62_RS04120 851487..853007 + 1521 WP_058612363.1 PH domain-containing protein -
JTZ62_RS04125 852997..853461 + 465 WP_058612362.1 PH domain-containing protein -
JTZ62_RS04130 853493..853855 + 363 WP_058591084.1 holo-ACP synthase -
JTZ62_RS04135 853903..855051 + 1149 WP_070369140.1 alanine racemase -
JTZ62_RS04140 855136..855303 + 168 WP_025904510.1 hypothetical protein Antitoxin
JTZ62_RS04145 855304..855675 + 372 WP_048540867.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JTZ62_RS04150 855772..856776 + 1005 WP_070373314.1 PP2C family protein-serine/threonine phosphatase -
JTZ62_RS04155 856881..857204 + 324 WP_206543273.1 anti-sigma factor antagonist -
JTZ62_RS04160 857209..857685 + 477 WP_025904514.1 anti-sigma B factor RsbW -
JTZ62_RS04165 857660..858430 + 771 WP_037589755.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13653.83 Da        Isoelectric Point: 9.9193

>T195459 WP_048540867.1 NZ_CP071138:855304-855675 [Mammaliicoccus sciuri]
MRRGDVYLADLSPVTGSEQGGTRPVVIIQNDTGNRYSPTVIVAAITGKINKAKIPTHVEIEAAKYKLDRDSVILLEQIRT
IDKKRLKEKLTYLSDAKMKEVDIAIAISLNLTLQQKFDTLGNT

Download         Length: 372 bp

>T195459 NZ_CP094729:847663-847872 [Staphylococcus epidermidis]
ATGAAATTGAAAAAAGGATTGATACATGTTTCAGGTATTAAAACAACTGAACAAGAGAAACAGCTCAAAGATCATTTATC
TAAGATGATAGGCATCAATAGTGTGGATATCGATTACCAAATGAATGAGATTCGAGTAGAATTTGACACTCCCGCAAATT
TAAATAACATTGAAAAAGAAATTTACGATTGCGGATTTCGTATTTTATAA

Antitoxin


Download         Length: 56 a.a.        Molecular weight: 6136.65 Da        Isoelectric Point: 4.0121

>AT195459 WP_025904510.1 NZ_CP071138:855136-855303 [Mammaliicoccus sciuri]
MTSLTQNRTQSLEQTLKEGYRSMADLNLSLASEAYYCECEACDSNESHIASQQGE

Download         Length: 168 bp

>AT195459 NZ_CP094729:847363-847656 [Staphylococcus epidermidis]
ATGGCAGACATGGAGAGTGCACATCACTCAGAGCAAATAAAAACAAATTTAAAATCAAGATTAAATAGAATAGAAGGTCA
AGTAAGAGCAATCAATCGTATGATTGATGACGATGTTTACTGTGATGATGTACTAACTCAAATTAGAGCAACACGTTCAG
CATTGAATAGTGTAGCTATTAAATTACTAGATCATCACATGAAGGGTTGTATTATGGAAAAAATAAACGACGGTGCGCAA
GAAGAAGCAATGGATGAATTGCTCGTGACATTCCAAAAATTAATAAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A418JBZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A657XHG2

References