Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1369263..1370038 Replicon chromosome
Accession NZ_CP071137
Organism MAG: Ferrovum myxofaciens isolate MI1III

Toxin (Protein)


Gene name tacT Uniprot ID A0A859A802
Locus tag JZL65_RS06760 Protein ID WP_031596033.1
Coordinates 1369263..1369757 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A859AAZ0
Locus tag JZL65_RS06765 Protein ID WP_031596032.1
Coordinates 1369754..1370038 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL65_RS06745 (JZL65_06775) 1365073..1368126 - 3054 WP_273146015.1 PAS domain S-box protein -
JZL65_RS06750 (JZL65_06780) 1368325..1368576 + 252 WP_031596035.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JZL65_RS06755 (JZL65_06785) 1368573..1368959 + 387 WP_031596034.1 type II toxin-antitoxin system VapC family toxin -
JZL65_RS06760 (JZL65_06790) 1369263..1369757 - 495 WP_031596033.1 GNAT family N-acetyltransferase Toxin
JZL65_RS06765 (JZL65_06795) 1369754..1370038 - 285 WP_031596032.1 DUF1778 domain-containing protein Antitoxin
JZL65_RS06770 (JZL65_06800) 1370313..1370528 - 216 WP_273146017.1 hypothetical protein -
JZL65_RS06775 (JZL65_06805) 1371368..1372234 + 867 WP_273146019.1 hypothetical protein -
JZL65_RS06780 (JZL65_06810) 1372445..1373431 + 987 WP_273146021.1 GTP 3',8-cyclase MoaA -
JZL65_RS06785 (JZL65_06815) 1373471..1374010 + 540 WP_273121353.1 molybdopterin adenylyltransferase -
JZL65_RS06790 (JZL65_06820) 1374007..1374498 + 492 WP_273146023.1 molybdopterin-guanine dinucleotide biosynthesis protein B -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(4-93)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18208.89 Da        Isoelectric Point: 8.5067

>T195452 WP_031596033.1 NZ_CP071137:c1369757-1369263 [Ferrovum myxofaciens]
MSLSAPQSLDANHRLEEFDCGKPALTDWLLRHARQAQGSGSAKTFVACDGSRVAGYFSLTVGQIDTLEAPERIRRGMGQY
PIPLVILARLAVDLDYQKQGLGFSLLQDAIRRTVAIAEHAGIRALLTHPIDAEAETFYRRFGFASTPVREQQLILLLKDA
RRFV

Download         Length: 495 bp

>T195452 NZ_CP094726:882594-882956 [Staphylococcus epidermidis]
ATGATTAGAAGAGGAGATGTTTATTTAGCGGATTTATCACCAGTTCAAGGGTCTGAACAAGGGGGAGTAAGACCTGTAGT
TATCATTCAAAATGATACTGGTAATAAATATAGTCCAACTGTAATTGTAGCTGCGATTACTGGTAGGATTAATAAAGCGA
AAATACCAACCCACGTAGAAATTGAAAAGAAAAAGTATAAATTAGACAAAGATTCAGTTATTCTTCTTGAACAAATTAGA
ACACTAGATAAAAAGCGTTTAAAAGAAAAATTAACATTTTTATCAGAGAGTAAAATGATAGAGGTTGATAATGCCTTAGA
TATTAGTTTGGGATTAAATAACTTTGATCATCATAAATCTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10516.92 Da        Isoelectric Point: 6.4651

>AT195452 WP_031596032.1 NZ_CP071137:c1370038-1369754 [Ferrovum myxofaciens]
MTATTTARSARLGLRATPEQETVLRRAAEVAHKSLTDFILDAAYQAAEHTLLDQRLFMVSGSQYQALLEMLDRPESDNPG
LANLFSRRPVWAEK

Download         Length: 285 bp

>AT195452 NZ_CP094726:882427-882597 [Staphylococcus epidermidis]
ATGTTATCTTTTAATCAAAATAGAAACCACAGTCTTGAACAATCTTTAAAAGAAGGTTATGCACAAATGGCCGATTTAAA
CCTCTCCCTAGCAACAGAAGCTTTTCCGATAGAGTGTGAAGCTTGTGATTGCAATGAATCACATTTAATATCTAATTCAA
AGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References