Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3826269..3826954 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JZL63_RS17795 Protein ID WP_206280491.1
Coordinates 3826544..3826954 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JZL63_RS17790 Protein ID WP_206280490.1
Coordinates 3826269..3826547 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS17770 3822258..3823859 - 1602 WP_206280489.1 FAD/NAD(P)-binding protein -
JZL63_RS17775 3823876..3824580 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
JZL63_RS17780 3824698..3825264 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
JZL63_RS17785 3825326..3826213 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
JZL63_RS17790 3826269..3826547 + 279 WP_206280490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JZL63_RS17795 3826544..3826954 + 411 WP_206280491.1 PIN domain-containing protein Toxin
JZL63_RS17800 3826987..3828723 - 1737 WP_206280492.1 FAD-binding protein -
JZL63_RS17805 3828779..3829906 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
JZL63_RS17810 3829926..3831515 - 1590 WP_206280493.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14582.68 Da        Isoelectric Point: 5.1784

>T195449 WP_206280491.1 NZ_CP071128:3826544-3826954 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVEMRVVARYGQPGQTERARYLLDGLDILPLTEPVIGL
AETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T195449 NZ_CP094725:927401-927760 [Staphylococcus felis]
ATGAAGCGAGGAGACGTTTATTTAGCAGATCTCTCTCCAGTACAAGGGTCCGAACAAGGGGGAGTAAGACCCGTCGTTAT
TATTCAAAATGATACTGGAAACAAATACAGTCCAACAGTTATAGTTGCTGCTATAACAGGTAGGATTAATAAAGCTAAAA
TACCCACTCATGTTGAAATTGAAAAACAGAAATATAAGTTAGACAAAGATTCTGTTATCCTGTTAGAACAAATTAGAACA
GTAGATAAAAAGAGGCTGAAGGAGAAATTGACATATTTATCAGATGAGAAGATGAAGGAAGTCAATAATGCTCTTGGTAT
CAGCTTAGGATTGCATATGAATCAGTCTAAAAAAGACTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10211.64 Da        Isoelectric Point: 8.7365

>AT195449 WP_206280490.1 NZ_CP071128:3826269-3826547 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGSKRT
LSDVLNEMRDEQ

Download         Length: 279 bp

>AT195449 NZ_CP094725:927230-927400 [Staphylococcus felis]
ATGTCAACATTCAATCAAACAAGATTTAAAAATAATCTAGAACAGTCTTTAAAAGAAGGTTACGTACAAATGGCTGACCT
AAATCTCTCCCTAGCAACCGAAGCCTACTCAGTAGAATGTGAAGCTTGTGACTGTAACGAATCTCACTTAACGAATAGCA
AGGATGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References