Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3770769..3771298 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag JZL63_RS17550 Protein ID WP_003417760.1
Coordinates 3771041..3771298 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag JZL63_RS17545 Protein ID WP_003417757.1
Coordinates 3770769..3771044 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS17525 3767567..3769004 - 1438 Protein_3461 FAD-binding oxidoreductase -
JZL63_RS17530 3769107..3769496 + 390 WP_003417745.1 DUF732 domain-containing protein -
JZL63_RS17535 3769510..3769803 - 294 WP_003417749.1 DUF3017 domain-containing protein -
JZL63_RS17540 3769800..3770645 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
JZL63_RS17545 3770769..3771044 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
JZL63_RS17550 3771041..3771298 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
JZL63_RS17555 3771340..3772530 + 1191 WP_206280478.1 NADH:flavin oxidoreductase -
JZL63_RS17560 3772647..3773015 + 369 WP_003417765.1 FHA domain-containing protein -
JZL63_RS17565 3773012..3773563 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
JZL63_RS17570 3773570..3774151 - 582 WP_003417769.1 ATP/GTP-binding protein -
JZL63_RS17575 3774132..3774500 - 369 WP_003417772.1 DUF742 domain-containing protein -
JZL63_RS17580 3774478..3774870 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T195447 WP_003417760.1 NZ_CP071128:3771041-3771298 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T195447 NZ_CP094724:1798783-1798971 [Staphylococcus hominis]
ATGAGTACACATTTAACGATTTTACTTTGGCTGGGTATTATATTTGTTGTTGCTGCTTCAATTATATTAGGGTTATTGCT
AAAATCTAAAAAAGAAGAACGTAAAGAATCATATTTAGGCTTTACAGTCATCTTCTATATTTTTGGTTTTGCTTTACTGA
TATATATACTATTATTCGGTATTTTATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT195447 WP_003417757.1 NZ_CP071128:3770769-3771044 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT195447 NZ_CP094724:1798503-1798760 [Staphylococcus hominis]
ATGAATATTAATAAATTATTTTGGATTAATATTATGATTACCCTTTTATTTCTAGGTTTTAACATTATTGTCACCTATTT
TCCTAAGTTAGATGATTATTTCTGGCTCATACCTGGTTTAATCATATGTGGCCTCACTATTTCATTCAGTTTAATTGCCG
CTATCTTGGATAAAAACCTTATAAGCGAAATAATTTTTTTAACTAATCTAATCATTTTTTTATATTATATATATCCACTG
ATATATAACTTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References