Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3707638..3708312 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag JZL63_RS17375 Protein ID WP_003417282.1
Coordinates 3707638..3708066 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag JZL63_RS17380 Protein ID WP_003417286.1
Coordinates 3708070..3708312 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS17350 3703460..3703861 - 402 WP_003417264.1 cytidine deaminase -
JZL63_RS17355 3704002..3704436 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
JZL63_RS17360 3704433..3704867 + 435 WP_206280471.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
JZL63_RS17365 3704996..3706768 + 1773 WP_206280472.1 succinate dehydrogenase flavoprotein subunit -
JZL63_RS17370 3706768..3707559 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
JZL63_RS17375 3707638..3708066 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
JZL63_RS17380 3708070..3708312 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
JZL63_RS17385 3708434..3709048 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
JZL63_RS17390 3709045..3709710 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
JZL63_RS17395 3709711..3710244 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
JZL63_RS17400 3710241..3710330 - 90 WP_009934953.1 pterin-4-alpha-carbinolamine dehydratase moaB3 -
JZL63_RS17405 3710429..3711690 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T195446 WP_003417282.1 NZ_CP071128:c3708066-3707638 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T195446 NZ_CP094724:932513-932686 [Staphylococcus hominis]
ATTTTTATGAGTAAAGATAGTAAACGTAATTATCATGAAGACGAAAATGCAATGGTTCAAAATATGGATGATTTAGAAGC
ATTAGGAAAAGAAATGGAACAGATTTCTGAAGAAAATGATGAAGATAAATATAATCAAACACATGATTCAGAAGCGCGTT
CAGATTTAAATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT195446 WP_003417286.1 NZ_CP071128:c3708312-3708070 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT195446 NZ_CP094724:931891-932490 [Staphylococcus hominis]
ATGGCAATGAATTTTAAAGTATTTGAAGATAAACAACATGCAGCAGATTATGCTGGAGATATTATTAGAAAACAATTTAA
CAATAACCCAACTACCATTGCTGGATTCCATTTAAACAAGGATTCTGCACCTGTATTAGATGAACTAAAAAAGTCAGTTG
ATCGTAACGCTGTAGATTTTAGTCAAATTAATATTCTTGATTATGATGATAATCATTCGTTCTATGAAGCTTTAGGTGTA
CCTTCTGAGCAAGTATATTCTATTAGTCTTGATGATGATGCCGAATCATTAATCAATGATAGAATTAAAACAAAAGAAAA
TAAAGGGAAATTGACTTTACAAGTTGTTTCAATTGATAACACTGGACATTTAGATGTTAATATTCGTCAAGGTTTGATGA
AGGCACGTGAAATTATCTTAGTTGTAACTGGTGCTGAAAAAAGTGAAGTTATCAAACGATTATATGAAGAAAATGGTAAA
TCAAATTTTTTACCAGCTGATTTAAAAGTACATCGTATGGTAACTGTTGTTTTAGACAGAGCTGCTGCTGATGGATTACC
AGAAGATGTTAAAGAATACTTCACAGCGAGATTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References