Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3183134..3183821 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag JZL63_RS15015 Protein ID WP_003414624.1
Coordinates 3183378..3183821 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag JZL63_RS15010 Protein ID WP_003414620.1
Coordinates 3183134..3183391 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS14990 3178454..3179308 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
JZL63_RS14995 3179364..3180527 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JZL63_RS15000 3180544..3181758 - 1215 WP_206280378.1 site-2 protease family protein -
JZL63_RS15005 3181766..3183007 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
JZL63_RS15010 3183134..3183391 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
JZL63_RS15015 3183378..3183821 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
JZL63_RS15020 3183901..3184563 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
JZL63_RS15025 3184659..3184850 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JZL63_RS15030 3185182..3186930 + 1749 WP_206280379.1 redoxin domain-containing protein -
JZL63_RS15035 3187026..3187607 + 582 WP_003414644.1 fasciclin domain-containing protein -
JZL63_RS15040 3187707..3187973 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T195444 WP_003414624.1 NZ_CP071128:3183378-3183821 [Mycobacterium tuberculosis]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T195444 NZ_CP094724:790832-791041 [Staphylococcus hominis]
ATGTTAAACAGTAATATTGTATTTATAGATAACATTGAAACAGAAGAACAAGCACAAATGTTAAATGAACGTTTGTTAAA
TATGATTGGAGTACATACGGTATCAATCGATATAGAAAGAAATAAGATTAATGTTGAATATGAAACACCTACTAATTTAA
ATAGTATTGAAAAAGAAATTTATGACGCTGGATTTAAAGTACTTTCATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT195444 WP_003414620.1 NZ_CP071128:3183134-3183391 [Mycobacterium tuberculosis]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT195444 NZ_CP094724:790523-790816 [Staphylococcus hominis]
TTGGAAAATCAAAATCATGCCCATCATTCTGAGCAAGTTAAATTAAATTTAAAATCTCGATTAAATCGAATAGAAGGACA
AGTTAAAGCAATTAATCGAATGATTGATGAAGACGTCTACTGTGATGATGTATTAACTCAGATAAGAGCAACACGTTCAG
CACTTAATAGTGTTGCTACTAAGTTACTAGAACATCACATGAAAAGTTGTATTATGGAAAAAATAAATCAAGGTACGGAA
GAAGAAGCAATGGAAGAACTACTAGTGACATTTCAAAAACTAGTGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References