Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3177533..3178081 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag JZL63_RS14985 Protein ID WP_003414602.1
Coordinates 3177818..3178081 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag JZL63_RS14980 Protein ID WP_003414599.1
Coordinates 3177533..3177814 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS14955 3173156..3174013 - 858 WP_206280375.1 type I methionyl aminopeptidase -
JZL63_RS14960 3174055..3174639 - 585 WP_206280376.1 DUF1707 domain-containing protein -
JZL63_RS14965 3174743..3174991 + 249 WP_003913411.1 antitoxin VapB23 -
JZL63_RS14970 3174988..3175368 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
JZL63_RS14975 3175450..3177261 - 1812 WP_206280377.1 penicillin-binding transpeptidase domain-containing protein -
JZL63_RS14980 3177533..3177814 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
JZL63_RS14985 3177818..3178081 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZL63_RS14990 3178454..3179308 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
JZL63_RS14995 3179364..3180527 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
JZL63_RS15000 3180544..3181758 - 1215 WP_206280378.1 site-2 protease family protein -
JZL63_RS15005 3181766..3183007 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T195443 WP_003414602.1 NZ_CP071128:3177818-3178081 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T195443 NZ_CP094723:c1651982-1651761 [Staphylococcus sp. IVB6214]
GTGCATAGTAAAGTATGGTTATCTGGTCTCTCGAGCGAAGAACAAAAGCAACAGCTTGAATCGAGACTGAGCGATATGAT
TGGTGTTGAAGCGGTAGAAGTGAATATCGAATCACAAACAGTGACACTGACGTATGAAACACCAGCCAACTTGAATACAT
TGGAAAAAGAAATTTATGATGCAGGTTATCCTGTCATCAATTCATATAAAGGAGCGCGTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT195443 WP_003414599.1 NZ_CP071128:3177533-3177814 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT195443 NZ_CP094723:c1652283-1651996 [Staphylococcus sp. IVB6214]
ATGACAGAACATGCAAACCATTCTGACGTGACGAAGCGCAATTTACAATCCCGTTTGAATCGCATTGAAGGACAAGTCCG
AGCCATTAATCGTATGATTGAAGAAGACGTCTATTGCGATGATGTTCTGACTCAAATCCGTGCAACACGTTCTGCATTGA
ATGGTGTGGCATCCAAGCTGTTAGAACACCATATGAAAGGATGTATCATGCATAAGGTAGAAGGTGGCAATGAACATGAA
GCGATGGATGAGTTACTCGTGACTTTCCAAAAGTTGATGAAAGACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References