Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | abiEi-abiEii/AbiEii-AbiEi |
| Location | 3133705..3135479 | Replicon | chromosome |
| Accession | NZ_CP071128 | ||
| Organism | Mycobacterium tuberculosis strain 267/47W148 | ||
Toxin (Protein)
| Gene name | abiEi | Uniprot ID | P71626 |
| Locus tag | JZL63_RS14765 | Protein ID | WP_003414409.1 |
| Coordinates | 3133705..3134589 (-) | Length | 295 a.a. |
Antitoxin (Protein)
| Gene name | abiEii | Uniprot ID | - |
| Locus tag | JZL63_RS14770 | Protein ID | WP_206281283.1 |
| Coordinates | 3134592..3135479 (-) | Length | 296 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JZL63_RS14745 | 3128969..3129343 | - | 375 | WP_003414296.1 | type III-A CRISPR-associated protein Csm2 | - |
| JZL63_RS14750 | 3129340..3131769 | - | 2430 | WP_096874492.1 | type III-A CRISPR-associated protein Cas10/Csm1 | - |
| JZL63_RS14755 | 3131766..3132554 | - | 789 | WP_003917092.1 | CRISPR-associated endoribonuclease Cas6 | - |
| JZL63_RS14760 | 3132888..3133433 | - | 546 | WP_003913758.1 | DUF1802 family protein | - |
| JZL63_RS14765 | 3133705..3134589 | - | 885 | WP_003414409.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| JZL63_RS14770 | 3134592..3135479 | - | 888 | WP_206281283.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| JZL63_RS14775 | 3135784..3136329 | - | 546 | WP_095794191.1 | DUF1802 family protein | - |
| JZL63_RS14780 | 3136326..3136595 | - | 270 | WP_206280367.1 | DUF2277 family protein | - |
| JZL63_RS14785 | 3136616..3137008 | - | 393 | WP_003414492.1 | type II toxin-antitoxin system VapC family toxin | - |
| JZL63_RS14790 | 3137005..3137220 | - | 216 | WP_206281284.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| JZL63_RS14795 | 3137267..3138016 | + | 750 | WP_206280368.1 | enoyl-CoA hydratase | - |
| JZL63_RS14800 | 3138095..3139177 | - | 1083 | WP_003414499.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 295 a.a. Molecular weight: 33056.72 Da Isoelectric Point: 7.1520
>T195441 WP_003414409.1 NZ_CP071128:c3134589-3133705 [Mycobacterium tuberculosis]
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
VAGLTRALVARHALGRAEAYDAALLDVAQDHLLYLLSQTVQFGDNRLVFKGGTSLRKCRLGNVGRFSTDLDFSAPDDEVV
LEVCELIDGARVGGFEFGVQSTRGDGRHWQLRVRHTELGEPRIVASVEFARRPLALPSELLAFIQLPIHKAYGFGLPTLP
VVAEAEACAEKLARYRRVALARDLYDLNHFASRTIDEPLVRRLWVLKVWGDVVDDRRGTRPLRVEDVLAARSEHDFQPDS
IGVLTRPVAMAAWEARVRKRFAFLTDLDADEQRWAACDERHRREVENALAVLRS
Download Length: 885 bp
>T195441 NZ_CP094723:c1477087-1476929 [Staphylococcus sp. IVB6214]
ATGAATAAACAAGAAAATGAACATGGCATGGTCGACAGCTTTGAAGAAGTGGTTGAATTAGGTAAAGAGATGGAACAAAT
CTCTGAAGAAAATGATGAACAAAAATTTGAACAATCACATGAAGAAGCCGTTCGCAGTGATCGTGAAACAGATAAATAA
ATGAATAAACAAGAAAATGAACATGGCATGGTCGACAGCTTTGAAGAAGTGGTTGAATTAGGTAAAGAGATGGAACAAAT
CTCTGAAGAAAATGATGAACAAAAATTTGAACAATCACATGAAGAAGCCGTTCGCAGTGATCGTGAAACAGATAAATAA
Antitoxin
Download Length: 296 a.a. Molecular weight: 32324.20 Da Isoelectric Point: 9.4727
>AT195441 WP_206281283.1 NZ_CP071128:c3135479-3134592 [Mycobacterium tuberculosis]
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGHALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
VVSPAGADRRIPTWASRVVSGLARDRPVVVTKEDLTQRLTEAGCGRDPDSAIRELRRIGWLVQLPVKGTWAFIPPGEAAI
SDPYLPLRSWLARDQNAGFMLAGASAAWHLGYLDRQPDGRIPIWLPPAKRLPDGLASYVSVVRIPWNAADTALLAPRPAL
LVRRRLDLVAWATGLPALGPEALLVQIATRPASFGPWADLVPHLDDLVADCSDERLERLLSGRPTSAWQRASYLLDSGGE
PARGHALLAKRHTEVMPVTRFTTAHSRDRGESVWAPEYQLVDELVVPLLRVIGKA
Download Length: 888 bp
>AT195441 NZ_CP094723:c1477705-1477106 [Staphylococcus sp. IVB6214]
ATGGCAATGAATTTTAAAATTTTCAAAGATCAAGGAACGGCTGCAACGTTTGTAGCGGATATTTTAAGAAAGCAATTCAA
TAATAATCCAACAACAATTGCAGGAATTCATTTGAAAAATGACAGTGTACCTGTAAATGCAGCATTACAAGAAAATGTTG
AGAAAAACCCTGTTGATTTCAGTCAAATTCATATTTTAGATTATGATAAACAAACAAATTACTACAAAACATTAGGCGTA
CCAGAAAAGCAAATCCACGAAATTCCAGAAGATGAGAAGGTTGAATCTTTCATTAAACATCATGCAAAAACAAAAGAAAA
CAAAGGTAAATTAACGTTACAAGTTGTGACAATCGATTGTGATGGTAACATCGGTATTCCAATGAATGATGGTGTCTTGA
CTGCCCGTGAAGTTGTGCTTGTATTAACAGGTGCTGAAAAAGCAGAAGTAGCACGTAAGTTATATGAAGAGAATGGTAGC
ACGACATTCATTCCATCAAGTTTGAAAACACATCGCATGGTGAATGTTGTATTGGATGAAGCAGCTGCACAAGGGCTTCC
TGAAGATGTTAGAGCTTATTTCACAGCACGTTATGCTTAA
ATGGCAATGAATTTTAAAATTTTCAAAGATCAAGGAACGGCTGCAACGTTTGTAGCGGATATTTTAAGAAAGCAATTCAA
TAATAATCCAACAACAATTGCAGGAATTCATTTGAAAAATGACAGTGTACCTGTAAATGCAGCATTACAAGAAAATGTTG
AGAAAAACCCTGTTGATTTCAGTCAAATTCATATTTTAGATTATGATAAACAAACAAATTACTACAAAACATTAGGCGTA
CCAGAAAAGCAAATCCACGAAATTCCAGAAGATGAGAAGGTTGAATCTTTCATTAAACATCATGCAAAAACAAAAGAAAA
CAAAGGTAAATTAACGTTACAAGTTGTGACAATCGATTGTGATGGTAACATCGGTATTCCAATGAATGATGGTGTCTTGA
CTGCCCGTGAAGTTGTGCTTGTATTAACAGGTGCTGAAAAAGCAGAAGTAGCACGTAAGTTATATGAAGAGAATGGTAGC
ACGACATTCATTCCATCAAGTTTGAAAACACATCGCATGGTGAATGTTGTATTGGATGAAGCAGCTGCACAAGGGCTTCC
TGAAGATGTTAGAGCTTATTTCACAGCACGTTATGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|