Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 3110163..3110733 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name mazF Uniprot ID P71650
Locus tag JZL63_RS14640 Protein ID WP_003414166.1
Coordinates 3110163..3110519 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID P0CL61
Locus tag JZL63_RS14645 Protein ID WP_003901465.1
Coordinates 3110503..3110733 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS14620 3105615..3107303 - 1689 WP_206280361.1 alpha/beta hydrolase family protein -
JZL63_RS14625 3107307..3107633 - 327 WP_003414157.1 hypothetical protein -
JZL63_RS14630 3107806..3108393 + 588 WP_003914429.1 DUF3558 family protein -
JZL63_RS14635 3108412..3110061 + 1650 WP_206280362.1 CocE/NonD family hydrolase -
JZL63_RS14640 3110163..3110519 - 357 WP_003414166.1 type II toxin-antitoxin system toxin endoribonuclease MazF9 Toxin
JZL63_RS14645 3110503..3110733 - 231 WP_003901465.1 antitoxin MazE Antitoxin
JZL63_RS14650 3110776..3111819 - 1044 WP_003414172.1 DUF2293 domain-containing protein -
JZL63_RS14655 3112010..3112285 + 276 WP_003911993.1 DUF1778 domain-containing protein -
JZL63_RS14660 3112461..3112715 - 255 WP_003917684.1 hypothetical protein -
JZL63_RS14665 3112863..3113267 + 405 WP_206281282.1 hypothetical protein -
JZL63_RS14670 3113264..3113455 + 192 WP_003414184.1 hypothetical protein -
JZL63_RS14675 3113519..3114808 + 1290 Protein_2896 transposase family protein -
JZL63_RS14680 3115042..3115299 + 258 WP_003899489.1 hypothetical protein -
JZL63_RS14685 3115404..3115715 + 312 WP_003414190.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-29)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12858.73 Da        Isoelectric Point: 9.1962

>T195440 WP_003414166.1 NZ_CP071128:c3110519-3110163 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS

Download         Length: 357 bp

>T195440 NZ_CP094722:c1693967-1693746 [Staphylococcus sp. IVB6218]
GTGCACAGCAAAGTATGGTTATCAGGTCTCTCGAGTGAGGAGCAAAAGCAACAGCTTGAATCGCGCCTGAGAGATATGAT
TGGTGTTGAAACGGCAGAGGTCGACATCGACAAGCAAATTGTGATTTTGACGTATGAAACCCCAGCCAATCTAAACACAT
TAGAAAAAGAAATTTATGATGCAGGTTACCCTGTTATTAATTCATATAAAGGAGAAGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8231.01 Da        Isoelectric Point: 4.1809

>AT195440 WP_003901465.1 NZ_CP071128:c3110733-3110503 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR

Download         Length: 231 bp

>AT195440 NZ_CP094722:c1694268-1693981 [Staphylococcus sp. IVB6218]
ATGATAGAACATGCGAATCATTCTGAAGTGACAAAACGCAATTTGCAATCCCGTTTAAATCGCATTGAAGGTCAAGTGCG
TGCAATTAATCGTATGATTGAAGAAGATGTTTATTGTGATGATGTCTTAACACAAATTCGTGCTACGAGATCGGCTTTAA
ATAGTGTAGCTTCGAAATTGTTAGAACATCATATGAAAGGGTGTATTTTGCATAAAGTTGAAGGTGGGAATGAGCAAGAA
GCAATGGATGAATTGCTTGTGACATTCCAAAAGTTGATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L2A
PDB 5HJZ
PDB 6KYT
PDB 6L29
PDB 7DU5
PDB 6KYS

Antitoxin

Source ID Structure
PDB 7DU5
PDB 6KYT
AlphaFold DB A0A7U4FBW3

References