Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402190..2402719 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JZL63_RS11150 Protein ID WP_003411124.1
Coordinates 2402190..2402507 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JZL63_RS11155 Protein ID WP_003411127.1
Coordinates 2402504..2402719 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS11120 2397327..2398403 + 1077 WP_003411110.1 hypothetical protein -
JZL63_RS11125 2398400..2398681 + 282 WP_003411112.1 hypothetical protein -
JZL63_RS11130 2398717..2399790 + 1074 WP_206281270.1 quinone-dependent dihydroorotate dehydrogenase -
JZL63_RS11135 2399795..2400325 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JZL63_RS11140 2400373..2401719 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JZL63_RS11150 2402190..2402507 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JZL63_RS11155 2402504..2402719 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JZL63_RS11160 2402974..2404032 + 1059 WP_206280206.1 hypothetical protein -
JZL63_RS11165 2404162..2404518 - 357 WP_003411130.1 hypothetical protein -
JZL63_RS11170 2404613..2405395 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JZL63_RS11175 2405663..2405953 - 291 WP_003900476.1 YggT family protein -
JZL63_RS11180 2406115..2406771 - 657 WP_206280207.1 cell division protein SepF -
JZL63_RS11185 2406840..2407613 - 774 Protein_2211 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T195430 WP_003411124.1 NZ_CP071128:c2402507-2402190 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T195430 NZ_CP094719:c1742684-1742463 [Staphylococcus sp. IVB6238]
GTGCACAGCAAAGTATGGTTATCAGGTCTCTCGAGTGAGGAGCAAAAGCAACAGCTTGAATCGCGCCTGAGAGATATGAT
TGGTGTTGAAACGGCAGAGGTCGACATCAACAAGCAAATTGTGATTTTGACGTATGAAACCCCAGCCAATCTAAACACAT
TAGAAAAAGAAATTTATGATGCAGGTTACCCTGTTATTAATTCATATAAAGGAGAAGATTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT195430 WP_003411127.1 NZ_CP071128:c2402719-2402504 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT195430 NZ_CP094719:c1742985-1742698 [Staphylococcus sp. IVB6238]
ATGATAGAACATGCGAATCATTCTGAAGTGACAAAACGCAATTTGCAATCCCGTTTAAATCGCATTGAAGGTCAAGTGCG
TGCAATTAATCGTATGATTGAAGAAGATGTTTATTGTGATGATGTCTTAACACAAATTCGTGCTACGAGATCGGCTTTAA
ATAGTGTAGCTTCGAAATTGTTAGAACATCATATGAAAGGGTGTATTTTGCATAAAGTTGAAGGTGGGAATGAGCAAGAA
GCAATGGATGAATTGCTTGTGACATTCCAAAAGTTGATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References