Detailed information of TA system TA195429

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2364083..2364778
• Replicon: chromosome
• Accession: NZ_CP071128
• Organism: Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JZL63_RS10945
• Protein ID: WP_206280200.1
• Coordinates: 2364083..2364517 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: JZL63_RS10950
• Protein ID: WP_003410814.1
• Coordinates: 2364524..2364778 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZL63_RS10935	2360237..2363278	+	3042	WP_206280198.1	DEAD/DEAH box helicase	-
JZL63_RS10940	2363271..2364104	+	834	WP_206280199.1	SWIM zinc finger family protein	-
JZL63_RS10945	2364083..2364517	-	435	WP_206280200.1	PIN domain-containing protein	Toxin
JZL63_RS10950	2364524..2364778	-	255	WP_003410814.1	antitoxin	Antitoxin
JZL63_RS10955	2364794..2365051	-	258	WP_003410816.1	hypothetical protein	-
JZL63_RS10960	2365462..2366723	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
JZL63_RS10965	2367356..2367652	+	297	WP_003410820.1	PE family protein	-
JZL63_RS10970	2367708..2368439	+	732	WP_003900467.1	PPE family protein	-
JZL63_RS10975	2368980..2369726	-	747	WP_206280201.1	proteasome subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15648.05 Da
• Isoelectric Point: 7.4681

>T195429 WP_206280200.1 NZ_CP071128:c2364517-2364083 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTSSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T195429 NZ_CP094719:c1728532-1728179 [Staphylococcus sp. IVB6238]
ATGAAGCGCGGGGATGTATACTTAGCTGATTTATCACCAGTACGGGGTTCTGAACAAGGGGGAGTGAGACCCGTCGTTAT
CATTCAAAATGATACTGGTAACAAATATAGTCCGACTGTTATCGTGGCAGCGATAACAGGTCGTATTAACAAAGCAAAGA
TTCCAACACATGTTGAAATTGAAAAAAAGAAGTATAAGCTCGACAAAGATTCAGTTATTTTATTAGAACAAATTCGAACA
GTAGATAAAAATCGTTTGAAAGAAAAGTTGACTTTTTTATCAGAAGAAAAGATGAAAGAAGTGAACAATGCTTTGGGGAT
TAGTCTTGGCTTACAAGTTGTTCAATCACGATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT195429 WP_003410814.1 NZ_CP071128:c2364778-2364524 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT195429 NZ_CP094719:c1728703-1728533 [Staphylococcus sp. IVB6238]
ATGTCAGTATTCAATCAAGTGAAGTTTAAAAATTTAGAGCAGTCATTAAAAGAAGGGTACGCCCAAATGGCTGACCTCAA
TCTCTCCCTAGCGACAGAAGCATATTCAGTAGAGTGTGAAGCATGCGATTGCAATGAGTCACACTTATTATCCAAGCATC
AGGATGATTAA

Structures

Antitoxin

• AlphaFold DB: G0TMN0