Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1967702..1968162 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name vapC Uniprot ID G0TKL9
Locus tag JZL63_RS09090 Protein ID WP_003898996.1
Coordinates 1967914..1968162 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ30
Locus tag JZL63_RS09085 Protein ID WP_003408528.1
Coordinates 1967702..1967914 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS09070 1964180..1965367 - 1188 WP_003898992.1 nitrate transporter NarK -
JZL63_RS09075 1965654..1965938 + 285 WP_003408522.1 DUF1876 domain-containing protein -
JZL63_RS09080 1965952..1967634 - 1683 WP_206281173.1 sulfate permease -
JZL63_RS09085 1967702..1967914 + 213 WP_003408528.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JZL63_RS09090 1967914..1968162 + 249 WP_003898996.1 type II toxin-antitoxin system VapC family toxin Toxin
JZL63_RS09095 1968170..1968907 + 738 WP_206281174.1 hypothetical protein -
JZL63_RS09100 1969001..1970701 + 1701 WP_003898998.1 serine/threonine protein kinase PknE -
JZL63_RS09105 1970986..1971387 - 402 WP_003408538.1 hypothetical protein -
JZL63_RS09110 1971377..1971988 - 612 WP_003898999.1 isopentenyl-diphosphate Delta-isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin VapB-like

(2-69)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8884.14 Da        Isoelectric Point: 4.1074

>T195419 WP_003898996.1 NZ_CP071128:1967914-1968162 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Download         Length: 249 bp

>T195419 NZ_CP094717:c1468635-1468477 [Staphylococcus sp. IVB6246]
ATGAATAAACAAGAAAATGAACATGGCATGGTTGACAGCTTTGATGAAGTTGTTGAGTTAGGTAAAGAGATGGAACAAAT
CTCTGAAGAAAATGATGAAGAAAAGTATGAACAGTCACACGAGGAAGCGGTTCGTAGTGATCGTGAGACTGACGAATAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7607.80 Da        Isoelectric Point: 9.3146

>AT195419 WP_003408528.1 NZ_CP071128:1967702-1967914 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Download         Length: 213 bp

>AT195419 NZ_CP094717:c1469253-1468654 [Staphylococcus sp. IVB6246]
ATGGCAATGAACTTTAAAATTTTCAAAGATCAAAACACAGCTGCAACATTTGTAGCAGATATTTTAAGAAAACAATTTAG
CAATAATCCAACAACAATTGCAGGGATTCATTTAAAAAATGATGATGCACCGGTTAATGGCGCTTTACAAATTAATGTTG
AAAATAATCCGGTAGATTTTAGTCAAATTCACATTTTAGACTATGATAAAAATGATGCATATTTTAAAGCATTAGGTGTA
CCTGAGAAACAAATTCACGAAATCCCAGAAGATGAAAAAGTAGAAGCATTCATCAAGCATCATGCAAAAACAAAAGAAAA
TAAAGGTAAGCTAACGTTACAAGTCGTGACAATTGATACAGATGGAAGTATTGGTATTCCAATGAATGATGCTGTGTTAA
CGGCACGTGAAATCGTTCTTGTATTAACAGGTGCTGAAAAAGCTGAAGTGGTACGTAAGTTATACGAAGAAAACGGCAGT
ACAACATTTGTCCCATCAAGTTTAAAATCTCATCGTATGGTCAATGTTGTTTTAGATGAAGCAGCAGCACAAGGCTTACC
AGAAGATGTTAGAGCTTATTTCTCAGCACGTTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TKL9

Antitoxin

Source ID Structure
AlphaFold DB A0A829CFE8

References