Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1574109..1574764 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag JZL63_RS07310 Protein ID WP_003898861.1
Coordinates 1574109..1574510 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag JZL63_RS07315 Protein ID WP_003407272.1
Coordinates 1574507..1574764 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS07295 1569581..1570966 - 1386 WP_206281087.1 cytochrome P450 -
JZL63_RS07300 1571044..1572078 + 1035 WP_003407264.1 AraC family transcriptional regulator -
JZL63_RS07305 1572124..1573854 - 1731 WP_206281088.1 PE domain-containing protein -
JZL63_RS07310 1574109..1574510 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
JZL63_RS07315 1574507..1574764 - 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
JZL63_RS07320 1574847..1575806 - 960 WP_003407276.1 alpha/beta hydrolase -
JZL63_RS07325 1575831..1576793 - 963 WP_206281089.1 alpha/beta hydrolase fold domain-containing protein -
JZL63_RS07330 1576792..1577529 + 738 WP_031647000.1 lysoplasmalogenase -
JZL63_RS07335 1577610..1579577 + 1968 WP_003407285.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T195415 WP_003898861.1 NZ_CP071128:c1574510-1574109 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T195415 NZ_CP094715:809324-809530 [Staphylococcus pasteuri]
GTGCAACAAAAAATCGTTTATACTTCAGGAATCAAAACGACTGAACAAGGTAACAAAATGGAAACAATATTAAAGGAAAT
GATAGGTGTATATGATGCAAATGTAGATTTAAGCAATGGTCACATTTCAGTTGAATTTGAGACACCTGCTAATTTAAATA
GTATCGAAAAAGAAATTTATGATTCTGGATTTAAAGTGCTTTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT195415 WP_003407272.1 NZ_CP071128:c1574764-1574507 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT195415 NZ_CP094715:809020-809313 [Staphylococcus pasteuri]
GTGACAGAACAAGATCATGCACATCACTCAGAACAAATTAAAACAAATTTGAAATCAAGATTAAATAGAATTGAAGGACA
AGTTCGTGCTATCAACCGAATGATAGAAGAAGATGTTTATTGTGATGATGTTTTAACACAAATTAGAGCAACACGTTCAG
CTTTAAATAGTGTAGCTACTAAATTATTAGAACAACATATGAAGAGTTGTATAACTGAAAAAGTCAATAATGGTCATCAA
GAAGAAGCCATGGAAGAGTTACTTGTAACTTTTCAAAAATTAATGAAAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References