Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PhRel-ATphRel/-
Location 1538387..1539437 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name phRel Uniprot ID G0TIH2
Locus tag JZL63_RS07155 Protein ID WP_003407164.1
Coordinates 1538387..1539208 (+) Length 274 a.a.

Antitoxin (Protein)


Gene name ATphRel Uniprot ID A0A7U4BTV8
Locus tag JZL63_RS07160 Protein ID WP_003407167.1
Coordinates 1539201..1539437 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS07135 1533945..1534607 - 663 WP_003407152.1 membrane protein -
JZL63_RS07140 1534604..1535389 - 786 WP_003407157.1 membrane protein -
JZL63_RS07145 1535680..1537641 - 1962 WP_206281075.1 SpoIIE family protein phosphatase -
JZL63_RS07150 1537780..1538166 - 387 WP_003898845.1 anti-sigma-F factor antagonist RsfA -
JZL63_RS07155 1538387..1539208 + 822 WP_003407164.1 GTP pyrophosphokinase family protein Toxin
JZL63_RS07160 1539201..1539437 + 237 WP_003407167.1 hypothetical protein Antitoxin
JZL63_RS07165 1539509..1540714 - 1206 WP_206281076.1 serine hydrolase -
JZL63_RS07170 1541017..1541802 + 786 WP_206281077.1 LppX_LprAFG lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(76-174)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 274 a.a.        Molecular weight: 30100.10 Da        Isoelectric Point: 5.8187

>T195414 WP_003407164.1 NZ_CP071128:1538387-1539208 [Mycobacterium tuberculosis]
VVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKS
QDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVE
IQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Download         Length: 822 bp

>T195414 NZ_CP094715:c34477-34139 [Staphylococcus pasteuri]
ATGAGTATAAAACAATTCGACATACTTTATATTGACCTAGATCCAACACGTGGTCGTGAAAAACAAAAGATACGTCCATG
TCTAGTTATAAACAATCAAATGAGCATTGAAGGTACTGATTTTGTTTGGGTATTACCAATCACAAATCGAGAAGTAAGAT
TTCCCACTGACATTGAAGTCAAAACTAAAAAAGGATTAGTTACAGGTGTCATAGATACTATTCAAATACGCTCACTAGAT
CTCAATGTTCGTTATCATAACTATAGAGATGAATTACAAGACAACTTAAAAAAGGATGTACTACAAGCGGTACAGACGTA
TTTAAAACCTACTTTATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8830.90 Da        Isoelectric Point: 7.3178

>AT195414 WP_003407167.1 NZ_CP071128:1539201-1539437 [Mycobacterium tuberculosis]
VGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR

Download         Length: 237 bp

>AT195414 NZ_CP094715:c34722-34474 [Staphylococcus pasteuri]
ATGAATAAAACGTCTGAACGCATTTTCAAAAATGGTAATAGTAAAGCTATGAGCTTAAGTAAACAAACGATTCAACTCGC
TAATTTCGACGTAGGGGATAAAGTTGAGGTTCAAGAAATGAATGGTGGATTATTTATCAAAAAAAAAGAAGAATCGATTG
AAGATAGAATTACAAATTTTTTCAAGAATGGTGGTAAATACACTGAAACTGAAATTGATTTTGTCGAAAGTGTAGGTCGT
GAGATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TIH2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BTV8

References