Detailed information of TA system TA195413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1388682..1389241
• Replicon: chromosome
• Accession: NZ_CP071128
• Organism: Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: JZL63_RS06505
• Protein ID: WP_003898789.1
• Coordinates: 1388682..1388975 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: JZL63_RS06510
• Protein ID: WP_003406322.1
• Coordinates: 1388972..1389241 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZL63_RS06480	1384275..1384535	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
JZL63_RS06485	1384532..1384963	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
JZL63_RS06490	1384986..1386674	-	1689	WP_206281041.1	PE domain-containing protein	-
JZL63_RS06495	1386854..1387714	+	861	WP_003900301.1	hypothetical protein	-
JZL63_RS06500	1387795..1388625	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
JZL63_RS06505	1388682..1388975	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
JZL63_RS06510	1388972..1389241	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JZL63_RS06515	1389354..1393049	-	3696	WP_206281042.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
JZL63_RS06520	1393191..1393979	-	789	WP_003406325.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T195413 WP_003898789.1 NZ_CP071128:c1388975-1388682 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T195413 NZ_CP094714:2491467-2491733 [Staphylococcus schleiferi]
ATGAGTTATTACAGCGTCTTGATTAAAAATTCAGCTAAAAGTGATTTGAAAAAAATCAACAAATCGCACCTCAAAGAACA
ATTTTTAAATGTTGTTGAAACTTTAAAAATTGATCCTTATGAACCTAGTCAATCTTTTGAAAAGTTACAACCAAAGCATT
TAGGACGTTATTCAAGACGTATTAATCATCAGCATAGAGTTGTTTATACGGTTGATGATGAAAAGAGAGAGGTTTATATA
TTTTCTACTTGGTCGCATTATGAGTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT195413 WP_003406322.1 NZ_CP071128:c1389241-1388972 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT195413 NZ_CP094714:2491210-2491467 [Staphylococcus schleiferi]
ATGAATATCAAAACACCTACAAATGCCAGAAAAGAATTTTATGAATTATTAAAACATGTAAATGTTAATCATGAGCCAGT
TATTATAAGTGGTTCTAAAAGTGAAAATAACGCAGTTATTGTAAGTCAAAAAGATTGGAATAGTATTCAAGAAACGTTGT
TTCTTGAATCAACTGGCACTATGGATAAAGTGAGAAAACGTGAAAAGGATGATAGTGGTTATACAAATATTGAAGATTTA
GATTGGGGTAACTTGTAA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2