Detailed information of TA system TA195412

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1384275..1384963
• Replicon: chromosome
• Accession: NZ_CP071128
• Organism: Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0THR7
• Locus tag: JZL63_RS06485
• Protein ID: WP_003406304.1
• Coordinates: 1384532..1384963 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0THR6
• Locus tag: JZL63_RS06480
• Protein ID: WP_003406302.1
• Coordinates: 1384275..1384535 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZL63_RS06460	1379852..1380676	+	825	WP_003900298.1	trehalose ABC transporter permease SugB	-
JZL63_RS06465	1380681..1381862	+	1182	WP_003406299.1	trehalose ABC transporter ATP-binding protein SugC	-
JZL63_RS06470	1381939..1383039	-	1101	WP_206281040.1	magnesium/cobalt transporter CorA	-
JZL63_RS06475	1383210..1384199	+	990	WP_003406301.1	malate dehydrogenase	-
JZL63_RS06480	1384275..1384535	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	Antitoxin
JZL63_RS06485	1384532..1384963	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	Toxin
JZL63_RS06490	1384986..1386674	-	1689	WP_206281041.1	PE domain-containing protein	-
JZL63_RS06495	1386854..1387714	+	861	WP_003900301.1	hypothetical protein	-
JZL63_RS06500	1387795..1388625	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
JZL63_RS06505	1388682..1388975	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	-
JZL63_RS06510	1388972..1389241	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (2-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15873.08 Da
• Isoelectric Point: 5.8838

>T195412 WP_003406304.1 NZ_CP071128:1384532-1384963 [Mycobacterium tuberculosis]
VIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVD
LLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE

Nucleotide

• Length: 432 bp

>T195412 NZ_CP094714:999788-999940 [Staphylococcus schleiferi]
ATGAAAGATGATCAAAAACAATATGAAAATGAAATGGTCGAAGGTTTTGATGATGTCGTTGAATTAGGCAAAGAGATGGA
ACAAATTTCAGAAAAAAATGATCAAGATAAATTAAATCAAGATCATGATGCTGATATTCGATCAGATAAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9918.25 Da
• Isoelectric Point: 6.4755

>AT195412 WP_003406302.1 NZ_CP071128:1384275-1384535 [Mycobacterium tuberculosis]
MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLD
ATRRAR

Nucleotide

• Length: 261 bp

>AT195412 NZ_CP094714:999170-999769 [Staphylococcus schleiferi]
ATGGCAATGAATTTTAAAATATTTAAAGATGCAGAAACAGTGGCAAAATATACAGCAGATATCTTAAGAAAACAGCTTAA
TAATAATCCTACCTCAATTGTAGGTGTCCATTTAAATGAAGACCAAGCGCCGGTTTTAAATTTTTTAAAACAAGATGTTG
ATCGTCATAGTGTAGATTTTAGTCAAATTCATATTTTGGACTATGATAAGCAAGCGTCATTTTTTAAATCATTAGGCGTA
CCAGAGAAACAAGTGCATGAAGTTCCAGATGATGACAATGTTGAATCATTTATTGCCCATCATGCTAAAACAAAAGATAA
CAAAGGAAAATTAACGTTACAAGTATTAACTATTGATGAAAACGGACAAATTGGGTTACCAATGAATGATGCCGTAATGC
CAGCGCGTGAAATTATTGTCGTTGTCACAGGTTCAAATAAAGCGGCACAAGTTCAAAAGTTATATGAAGAAAATGGGAAT
ACAAGCTTTATTCCGTCAACATTAAAAACACATCGTATGGTGACTGTTGTCCTTGATGAAGCGGCTGCACAAGGTTTACC
AGATGATGTTAGAGCCTATTTTACTTCATTATATGCATAA

Structures

Toxin

• AlphaFold DB: G0THR7

Antitoxin

• AlphaFold DB: G0THR6