Detailed information of TA system TA195398

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 703243..703886
• Replicon: chromosome
• Accession: NZ_CP071128
• Organism: Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: JZL63_RS03170
• Protein ID: WP_206280897.1
• Coordinates: 703485..703886 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ91
• Locus tag: JZL63_RS03165
• Protein ID: WP_003403184.1
• Coordinates: 703243..703488 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZL63_RS03130	698523..699053	-	531	WP_003917320.1	two component system sensor kinase HK2	-
JZL63_RS03135	699037..699732	-	696	WP_206281233.1	response regulator	-
JZL63_RS03140	699855..700166	+	312	WP_003403164.1	hypothetical protein	-
JZL63_RS03145	700238..701188	+	951	WP_206280895.1	DUF1259 domain-containing protein	-
JZL63_RS03150	701429..702013	+	585	WP_206280896.1	IS607 family transposase	-
JZL63_RS03155	702015..702728	+	714	Protein_625	IS607 family element transposase accessory protein TnpB	-
JZL63_RS03160	702728..703198	+	471	WP_003898523.1	hypothetical protein	-
JZL63_RS03165	703243..703488	+	246	WP_003403184.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JZL63_RS03170	703485..703886	+	402	WP_206280897.1	PIN domain-containing protein	Toxin
JZL63_RS03175	704274..704441	-	168	WP_077385191.1	DUF3800 domain-containing protein	-
JZL63_RS03180	704474..704671	-	198	WP_003403191.1	hypothetical protein	-
JZL63_RS03185	704751..705908	-	1158	WP_003898524.1	hypothetical protein	-
JZL63_RS03190	705960..706181	-	222	WP_003898525.1	DUF4926 domain-containing protein	-
JZL63_RS03195	706323..706928	+	606	WP_003898526.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-80)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14516.18 Da
• Isoelectric Point: 4.4463

>T195398 WP_206280897.1 NZ_CP071128:703485-703886 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRQSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Nucleotide

• Length: 402 bp

>T195398 NZ_CP094707:969780-969986 [Staphylococcus simulans]
ATGCATAGTAGTGTGATTCAAATCAGTGGTATGGAAACTGAAGAACAACAGCATATTTTGCAAGAACATTTGCAGCAAAT
GATTGGTATGTCAGAAGTGCAAGTGGATCTGAAATCACAAGAAGTGAAAGCGAGTTACCAGACACCAATCAGTTTAAACA
ATTTGGAAAAAGAAATTTATGATCAAGGTTACCAAATATTAAATTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8813.12 Da
• Isoelectric Point: 10.3486

>AT195398 WP_003403184.1 NZ_CP071128:703243-703488 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Nucleotide

• Length: 246 bp

>AT195398 NZ_CP094707:969472-969765 [Staphylococcus simulans]
ATGACGCAAGAAGAACGCGCACATCATTCAGAAAAAATCAAATCTAACCTTAAAGCACGACTGAATCGTATAGAAGGACA
AGTCAGAGCGATTAATCGCATGATAGATGAAGATGTTTATTGTGATGATGTTTTAACACAAATCAGAGCGACACGTTCAG
CTTTGAATAGTGTTGCTGTAAAATTGCTGGATCATCATATGAAAGGCTGTATTTTGCATAAAGCTGAAGATGGACAAGCA
GAAGCTGCAATGGAAGAATTATTAGTTACCGTCCAAAAATTAATTAAAGATTAA

Structures

Antitoxin

• AlphaFold DB: G0TQ91