Detailed information of TA system TA195393

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 444221..445232
• Replicon: chromosome
• Accession: NZ_CP071128
• Organism: Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: L7N5R2
• Locus tag: JZL63_RS01910
• Protein ID: WP_003401859.1
• Coordinates: 444221..444814 (-)
• Length: 198 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: O53702
• Locus tag: JZL63_RS01915
• Protein ID: WP_003401860.1
• Coordinates: 444843..445232 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JZL63_RS01890	439870..441252	+	1383	WP_003898415.1	magnesium transporter	-
JZL63_RS01895	441264..442298	-	1035	WP_206280824.1	class II fructose-bisphosphate aldolase	-
JZL63_RS01900	442394..443077	+	684	WP_003401857.1	VTT domain-containing protein	-
JZL63_RS01905	443066..444196	-	1131	WP_003401858.1	hypothetical protein	-
JZL63_RS01910	444221..444814	-	594	WP_003401859.1	zeta toxin family protein	Toxin
JZL63_RS01915	444843..445232	-	390	WP_003401860.1	hypothetical protein	Antitoxin
JZL63_RS01920	445313..446524	-	1212	WP_206280826.1	VWA domain-containing protein	-
JZL63_RS01925	446530..447132	-	603	WP_003898417.1	SRPBCC family protein	-
JZL63_RS01930	447146..448042	-	897	WP_206280828.1	AAA family ATPase	-
JZL63_RS01935	448039..448632	-	594	WP_003401864.1	NTP transferase domain-containing protein	-
JZL63_RS01940	448629..449384	-	756	WP_003401865.1	XdhC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 198 a.a.
• Molecular weight: 21344.53 Da
• Isoelectric Point: 10.5018

>T195393 WP_003401859.1 NZ_CP071128:c444814-444221 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Nucleotide

• Length: 594 bp

>T195393 NZ_CP094702:1704966-1705439 [Staphylococcus simulans]
ATGGGAGTTTACGAAGATTTATGTATCGCTAACGATTGGGTTGAGATTGAGGAGACTGATCGTTTACCTAGTTTCCAACC
AGGGTTTTACAGAAATGGAAAAATCTATATTAAAAGCAGTCTTTCCGAAACACGCAAAGCTGAAGTTCTCTATGAAGAAT
TAGCTCACCATAAACTTACGTACGGAAACATACTTGATGAATCAAGCTTCAATAACCGTAAATTCGAAAATTACGCACGA
AGACATGGTTATGAAAATTCTATATCTTTAAACAAGATTATAGACGCATATAAATACGGAGTAAGTAGCTTACATGAATT
TGCTGAATATGTTCAATTAAGCGAAGAATACGTACATACAGTTTTACAACATTACAAAAACAAATTCGGTTTATCAACCT
GCCACAATGGTTATCTTATTCGTTTTGAGCCGTTGCAGGTTTTTAAATATAAAAATTTAAATGAAGGAGATTAG

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13648.21 Da
• Isoelectric Point: 6.0829

>AT195393 WP_003401860.1 NZ_CP071128:c445232-444843 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Nucleotide

• Length: 390 bp

>AT195393 NZ_CP094702:1704620-1704952 [Staphylococcus simulans]
ATGAGAACAAATGATGAAATAATCACAATAATAAAAACAACGTTAAAAGAACAAAATATGTCGCTTAGTGAATTAGCTCG
TCGTGTAGGAATGGCTAAATCAGCTGTATCGCGTTATTTAAACTTAACTAGAGAGTTTCCATTGAACCGTGCGGAAGATT
TTGCAAAAGCACTTCATATTAGTACAGAATATTTACTTGGTTTTACAGAAAGTGAACAAAAAGAGCAAGAACAAGACACT
ATGGCCGCTCATTTTGACAAAGAAGGTCTAACAGAAGAGGAAATTGAAGAAGTTAATAAGTTTATTGAATGGGTTAAGAA
TAGAGATAAGTAA

Structures

Toxin

• AlphaFold DB: A0A7U4BRU8

Antitoxin

• AlphaFold DB: A0A7U4BRT0