Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 71589..72222 Replicon chromosome
Accession NZ_CP071128
Organism Mycobacterium tuberculosis strain 267/47W148

Toxin (Protein)


Gene name vapC Uniprot ID P9WFC0
Locus tag JZL63_RS00360 Protein ID WP_003400580.1
Coordinates 71821..72222 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P0CW29
Locus tag JZL63_RS00355 Protein ID WP_003400577.1
Coordinates 71589..71828 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JZL63_RS00340 66923..68362 + 1440 WP_206280709.1 FAD-binding protein -
JZL63_RS00345 68418..68579 + 162 WP_003899796.1 hypothetical protein -
JZL63_RS00350 68620..71559 + 2940 WP_206280710.1 UPF0182 family protein -
JZL63_RS00355 71589..71828 + 240 WP_003400577.1 antitoxin VapB1 Antitoxin
JZL63_RS00360 71821..72222 + 402 WP_003400580.1 type II toxin-antitoxin system ribonuclease VapC1 Toxin
JZL63_RS00365 72274..74511 - 2238 WP_003899797.1 NADP-dependent isocitrate dehydrogenase -
JZL63_RS00370 74629..75198 - 570 WP_003400591.1 TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator -
JZL63_RS00375 75301..76212 + 912 WP_206280711.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(36-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14339.44 Da        Isoelectric Point: 4.8887

>T195389 WP_003400580.1 NZ_CP071128:71821-72222 [Mycobacterium tuberculosis]
VDECVVDAAAVVDALAGKGASAIVLRGLLKESISNAPHLLDAEVGHALRRAVLSDEISEEQARAALDALPYLIDNRYPHS
PRLIEYTWQLRHNVTFYDALYVALATALDVPLLTGDSRLAAAPGLPCEIKLVR

Download         Length: 402 bp

>T195389 NZ_CP094698:1685619-1686092 [Staphylococcus simulans]
ATGGGAGTTTACGAAGATTTATGTATCGCTAACGATTGGGTTGAGATTGAGGAGACTGATCGTTTACCTAGTTTCCAACC
AGGGTTTTACAGAAATGGAAAAATCTATATTAAAAGCAGTCTTTCCGAAACACGCAAAGCTGAAGTTCTCTATGAAGAAT
TAGCTCACCATAAACTTACGTACGGAAACATACTTGATGAATCAAGCTTCAATAACCGTAAATTCGAAAATTACGCACGA
AGACATGGTTATGAAAATTCTATATCTTTAAACAAGATTATAGACGCATATAAATACGGAGTAAGTAGCTTACATGAATT
TGCTGAATATGTTCAATTAAGCGAAGAATACGTACATACAGTTTTACAACATTACAAAAACAAATTCGGTTTATCAACCT
GCCACAATGGTTATCTTATTCGTTTTGAGCCGTTGCAGGTTTTTAAATATAAAAATTTAAATGAAGGAGATTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8717.84 Da        Isoelectric Point: 8.5960

>AT195389 WP_003400577.1 NZ_CP071128:71589-71828 [Mycobacterium tuberculosis]
MATIQVRDLPEDVAETYRRRATAAGQSLQTYMRTKLIEGVRGRDKAEAIEILEQALASTASPGISRETIEASRRELRGG

Download         Length: 240 bp

>AT195389 NZ_CP094698:1685273-1685605 [Staphylococcus simulans]
ATGAGAACAAATGATGAAATAATCACAATAATAAAAACAACGTTAAAAGAACAAAATATGTCGCTTAGTGAATTAGCTCG
TCGTGTAGGAATGGCTAAATCAGCTGTATCGCGTTATTTAAACTTAACTAGAGAGTTTCCATTGAACCGTGCGGAAGATT
TTGCAAAAGCACTTCATATTAGTACAGAATATTTACTTGGTTTTACAGAAAGTGAACAAAAAGAGCAAGAACAAGACACT
ATGGCCGCTCATTTTGACAAAGAAGGTCTAACAGAAGAGGAAATTGAAGAAGTTAATAAGTTTATTGAATGGGTTAAGAA
TAGAGATAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BR82

Antitoxin

Source ID Structure
AlphaFold DB A0A829CHM7

References