Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 3826265..3826950 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JY387_RS17815 Protein ID WP_206280491.1
Coordinates 3826540..3826950 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag JY387_RS17810 Protein ID WP_206280490.1
Coordinates 3826265..3826543 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS17790 3822254..3823855 - 1602 WP_003417969.1 FAD/NAD(P)-binding protein -
JY387_RS17795 3823872..3824576 - 705 WP_003417980.1 dTDP-4-amino-4,6-dideoxyglucose formyltransferase -
JY387_RS17800 3824694..3825260 - 567 WP_003417984.1 TetR/AcrR family transcriptional regulator -
JY387_RS17805 3825322..3826209 + 888 WP_003900050.1 alpha-ketoglutarate-dependent sulfate ester dioxygenase -
JY387_RS17810 3826265..3826543 + 279 WP_206280490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JY387_RS17815 3826540..3826950 + 411 WP_206280491.1 PIN domain-containing protein Toxin
JY387_RS17820 3826983..3828719 - 1737 WP_206280492.1 FAD-binding protein -
JY387_RS17825 3828775..3829902 - 1128 WP_003418005.1 GuaB3 family IMP dehydrogenase-related protein -
JY387_RS17830 3829922..3831511 - 1590 WP_206280493.1 IMP dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14582.68 Da        Isoelectric Point: 5.1784

>T195388 WP_206280491.1 NZ_CP071127:3826540-3826950 [Mycobacterium tuberculosis]
VIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVEMRVVARYGQPGQTERARYLLDGLDILPLTEPVIGL
AETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR

Download         Length: 411 bp

>T195388 NZ_CP094698:1002608-1002958 [Staphylococcus simulans]
ATGATGAGGAGAGGCGATGTTTATTTAGCTGATTTATCACCAGTGCAAGGTTCTGAACAAGGGGGAGTTAGACCTGTTGT
AATTATACAAAATGACACTGGCAATAAGTACAGTCCGACGGTAATTGTAGCCGCGATTACTGGGCGTATTAATAAGGCGA
AAATTCCAACACATGTTGAAATTGAAAAGAGTAAATACAAATTAGACAAAGATTCTGTTATATTACTTGAACAGATTAGA
ACAGTTGATAAAAAACGTTTGAAAGAGAAATTGACTTATCTTTCAGATGAGAAGATGAAAGAAATTGATAACGCGATTGG
AATTAGTTTAGGCTTGACACATAAAAATTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10211.64 Da        Isoelectric Point: 8.7365

>AT195388 WP_206280490.1 NZ_CP071127:3826265-3826543 [Mycobacterium tuberculosis]
VEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGSKRT
LSDVLNEMRDEQ

Download         Length: 279 bp

>AT195388 NZ_CP094698:1002444-1002611 [Staphylococcus simulans]
ATGTCAACTTTTAATCAGAATAGAAGCTATAGTTTGGAACAGTCATTAAAAGAAGGCTATTCACAAATGGCTGATTTGAA
TCTCTCCCTAGCAACGGAGGCATTTTCAGTGGAATGTGAAGCCTGTGATTGCAATGAATCTTATCTTACATTTGATAAGG
ATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References