195385

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3707634..3708308 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag JY387_RS17395 Protein ID WP_003417282.1
Coordinates 3707634..3708062 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag JY387_RS17400 Protein ID WP_003417286.1
Coordinates 3708066..3708308 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS17370 3703456..3703857 - 402 WP_003417264.1 cytidine deaminase -
JY387_RS17375 3703998..3704432 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
JY387_RS17380 3704429..3704863 + 435 WP_206280471.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
JY387_RS17385 3704992..3706764 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
JY387_RS17390 3706764..3707555 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
JY387_RS17395 3707634..3708062 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
JY387_RS17400 3708066..3708308 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
JY387_RS17405 3708430..3709044 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
JY387_RS17410 3709041..3709706 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
JY387_RS17415 3709707..3710240 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
JY387_RS17420 3710237..3710326 - 90 WP_009934953.1 pterin-4-alpha-carbinolamine dehydratase moaB3 -
JY387_RS17425 3710425..3711686 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T195385 WP_003417282.1 NZ_CP071127:c3708062-3707634 [Mycobacterium tuberculosis]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T195385 NZ_CP094697:985588-985794 [Staphylococcus simulans]
ATGCATAGTAGTGTGATTCAAATCAGTGGTATGGAAACTGAAGAACAACAGCATATTTTGCAAGAACATTTGCAGCAAAT
GATTGGTATGTCAGAAGTGCAAGTGGATCTGAAATCACAAGAAGTGAAAGCGAGTTACCAGACACCAATCAGTTTAAACA
ATTTGGAAAAAGAAATTTATGATCAAGGTTACCAAATATTAAATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT195385 WP_003417286.1 NZ_CP071127:c3708308-3708066 [Mycobacterium tuberculosis]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT195385 NZ_CP094697:985280-985573 [Staphylococcus simulans]
ATGACGCAAGAAGAACGCGCACATCATTCAGAAAAAATCAAATCTAACCTTAAAGCACGACTGAATCGTATAGAAGGACA
AGTCAGAGCGATTAATCGCATGATAGATGAAGATGTTTATTGTGATGATGTTTTAACACAAATCAGAGCGACACGTTCAG
CTTTGAATAGTGTTGCTGTAAAATTGCTGGATCATCATATGAAAGGCTGTATTTTGCATAAAGCTGAAGATGGACAAGCA
GAAGCTGCAATGGAAGAATTATTAGTTACCGTCCAAAAATTAATTAAAGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References