Detailed information of TA system TA195381

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN_Sll0205-like-Phd
• Location: 3136612..3137216
• Replicon: chromosome
• Accession: NZ_CP071127
• Organism: Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P71623
• Locus tag: JY387_RS14795
• Protein ID: WP_003414492.1
• Coordinates: 3136612..3137004 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JY387_RS14800
• Protein ID: WP_206281284.1
• Coordinates: 3137001..3137216 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY387_RS14765	3131762..3132550	-	789	WP_003917092.1	CRISPR-associated endoribonuclease Cas6	-
JY387_RS14770	3132884..3133429	-	546	WP_003913758.1	DUF1802 family protein	-
JY387_RS14775	3133701..3134585	-	885	WP_003414409.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
JY387_RS14780	3134588..3135475	-	888	WP_206281283.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
JY387_RS14785	3135780..3136325	-	546	WP_095794191.1	DUF1802 family protein	-
JY387_RS14790	3136322..3136591	-	270	WP_206337963.1	DUF2277 family protein	-
JY387_RS14795	3136612..3137004	-	393	WP_003414492.1	type II toxin-antitoxin system VapC family toxin	Toxin
JY387_RS14800	3137001..3137216	-	216	WP_206281284.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JY387_RS14805	3137263..3138012	+	750	WP_206280368.1	enoyl-CoA hydratase	-
JY387_RS14810	3138091..3139173	-	1083	WP_003414499.1	ABC transporter ATP-binding protein	-
JY387_RS14815	3139166..3140476	-	1311	WP_003414501.1	ABC transporter substrate-binding protein	-
JY387_RS14820	3140479..3141306	-	828	WP_003414504.1	carbohydrate ABC transporter permease	-
JY387_RS14825	3141303..3142214	-	912	WP_003414505.1	sugar ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (5-130)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-46)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14610.74 Da
• Isoelectric Point: 6.7594

>T195381 WP_003414492.1 NZ_CP071127:c3137004-3136612 [Mycobacterium tuberculosis]
MTTVLLDSHVAYWWSAEPQRLSMAASQAIEHADELAVAAISWFELAWLAEQERIQLAIPVLSWLQQLAEHVRTVGITPSV
AATAVALPSSFPGDPADRLIYATAIEHGWRLVTKDRRLRSHRHPRPVTVW

Nucleotide

• Length: 393 bp

>T195381 NZ_CP094678:92351-92875 [Pseudomonas aeruginosa]
ATGAAAATCATCGGAGTGCAGGACCTCCCCTGCTACCGAATGCACACTCCCAAGTGGTCCGTTGCGCCTACATCTGGAGC
TGGAGCTGCAACTCAGGGTGGCCGGGTTAACCGAAAGGGGCTAGAGGCTCTATACCTCTCGCTTGAGTCGGCAACGGCCA
TTGCTGAGTTTCAGCAAGCAAGCGCATTCCTTCCTCCTGGTCTGCTGATCAGCTATTCCCTCAGTCTGGATCGAGTGATC
GACTTCACCGGCGGCTATAACGATACCTGGGCCCCGATCTGGCAAGACTTCTTCTGCGACTGGAGAAAGATTCGCTTCAA
CGACGGCGTTGAGCCGCCGAGCTGGATTATCGGAGATCTGGCTATCGAGGCTGACTGTGCTGGGATTCTGTTCGAGTCCG
TTGCGAACCCTGGAGGTCGGAACCTGGTGCTTTTCACCGATCAGTTGCCGGTGCATGGGAATATTGTGGTCAACGATCCT
CGCGGGGATCTCCCTACCGACCAGTCATCTTGGACGCGCCCGTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 7511.55 Da
• Isoelectric Point: 4.9732

>AT195381 WP_206281284.1 NZ_CP071127:c3137216-3137001 [Mycobacterium tuberculosis]
MTATEVKAKILSLLDEVAQGEEIEITKHGRTVARLVAATGPHALKGRFSGVAMAAVDDDELFTTGVSWNVS

Nucleotide

• Length: 216 bp

>AT195381 NZ_CP094678:91959-92354 [Pseudomonas aeruginosa]
ATGGCCAGCAAAGCCGTATTAGAGCTTCGCCCCACCAACTTCGCGGGCTTGATGGACGCTCTCAAAGAGGTGAACCGTGT
GATGTTCTCTCCTGAGCGCTTCCTCAAGGTTTTTTCGATGGACCAGCAGACCTTGGCGCTCCGGGCCCATGTCCATCGCA
ACACTGTGCGCAACGCGCCTGAATCGGAAAAGGTCCAGGCCTACATTCGTGATTCAGTGAAGGTTCTGCGCGCAGTGACC
GACATGGGCACGGACGTGACGAATGCCATCTTCTGGTTTAAGAACGAGCCTCTTTCCACGTTCGGCTATAAGACCGCGGA
GGAAGTGGTCAGCGAAGGAAAAACCGAGCAGCTGATCGCTTTCCTTCAATCTTGGGAAGCTGGTGCCCAAGGATGA

Structures

Toxin

• AlphaFold DB: A0A7U4BWM8