195375

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2930062..2930776 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag JY387_RS13615 Protein ID WP_003413460.1
Coordinates 2930336..2930776 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag JY387_RS13610 Protein ID WP_003413456.1
Coordinates 2930062..2930349 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS13575 2925484..2925729 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
JY387_RS13580 2925726..2926130 + 405 WP_206280312.1 PIN domain-containing protein -
JY387_RS13585 2926347..2926967 + 621 WP_003413441.1 DUF4178 domain-containing protein -
JY387_RS13590 2926978..2927472 + 495 WP_003413444.1 DUF2617 family protein -
JY387_RS13595 2927469..2927900 + 432 WP_003899390.1 DUF4247 domain-containing protein -
JY387_RS13600 2927925..2928383 + 459 WP_206280313.1 DUF350 domain-containing protein -
JY387_RS13605 2928380..2929951 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
JY387_RS13610 2930062..2930349 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
JY387_RS13615 2930336..2930776 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
JY387_RS13620 2930797..2931552 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
JY387_RS13625 2931685..2932281 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
JY387_RS13630 2932289..2933134 - 846 WP_003413466.1 acyl-CoA thioesterase II -
JY387_RS13635 2933163..2934062 - 900 WP_206280314.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
JY387_RS13640 2934190..2934864 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T195375 WP_003413460.1 NZ_CP071127:2930336-2930776 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T195375 NZ_CP094676:6467882-6468136 [Streptomyces sp. CB09030]
GTGAGGGTCACTTTCACGTCCCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGGTGACCAAGCGGAT
CAACAGACTGATCGACGACATCACCCGTGACCCGTTCAAGGGCATCGGGAAGCCGGAGCCGCTCAAGGGCGACCTGTCGG
GCTACTGGTCACGGCGCATCGACGACACGCACCGGCTCGTGTACAAGCCCGCCGACGGCGTACTGGTCATCGTGCAGGCC
CGCTACCACTACTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT195375 WP_003413456.1 NZ_CP071127:2930062-2930349 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT195375 NZ_CP094676:6467622-6467885 [Streptomyces sp. CB09030]
ATGCCCATCACCGCCAGCGAAGCCCGTCAGAACCTGTTCCCGCTGATAGAGCAGGTCAACGAGGACCACGCCCCGGTACA
CATCACCTCCCGCAAGGGAAACGCCGTACTCATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACGGTGCACCTCCTGC
GCTCGCCCAAGAACGCCCGCCGTCTGCTCGACTCCATCGCGGAGGCCGAAGCGGGCGAAGCACGGCATCGCGAGCTGATC
GACCCGGACGCGGAGCGGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References