195374

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2869719..2870356 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name vapC Uniprot ID P0DMV7
Locus tag JY387_RS13350 Protein ID WP_003413180.1
Coordinates 2869719..2870114 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ44
Locus tag JY387_RS13355 Protein ID WP_003413183.1
Coordinates 2870111..2870356 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS13310 2865122..2866333 + 1212 WP_206337933.1 alpha/beta hydrolase family protein -
JY387_RS13315 2866460..2867119 + 660 WP_206337934.1 hypothetical protein -
JY387_RS13320 2867116..2867778 + 663 WP_206337935.1 hypothetical protein -
JY387_RS13325 2867775..2868053 + 279 WP_206280300.1 type II toxin-antitoxin system VapB family antitoxin -
JY387_RS13330 2868146..2868559 + 414 WP_003413164.1 PIN domain nuclease -
JY387_RS13335 2868598..2868855 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein -
JY387_RS13340 2868852..2869229 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin -
JY387_RS13345 2869245..2869619 - 375 WP_003413177.1 hypothetical protein -
JY387_RS13350 2869719..2870114 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 Toxin
JY387_RS13355 2870111..2870356 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 Antitoxin
JY387_RS13360 2870767..2871186 - 420 WP_003413190.1 A24 family peptidase -
JY387_RS13365 2871198..2872007 - 810 WP_003413193.1 shikimate dehydrogenase -
JY387_RS13370 2872004..2873257 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
JY387_RS13375 2873250..2873762 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Endonuclease VapC20-like

(1-129)

Antitoxin

Ribbon-helix-helix protein, CopG

(11-49)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14619.53 Da        Isoelectric Point: 6.9794

>T195374 WP_003413180.1 NZ_CP071127:c2870114-2869719 [Mycobacterium tuberculosis]
MIFVDTSFWAALGNAGDARHGTAKRLWASKPPVVMTSNHVLGETWTLLNRRCGHRAAVAAAAIRLSTVVRVEHVTADLEE
QAWEWLVRHDEREYSFVDATSFAVMRKKGIQNAYAFDGDFSAAGFVEVRPE

Download         Length: 396 bp

>T195374 NZ_CP094676:6467622-6467885 [Streptomyces sp. CB09030]
ATGCCCATCACCGCCAGCGAAGCCCGTCAGAACCTGTTCCCGCTGATAGAGCAGGTCAACGAGGACCACGCCCCGGTACA
CATCACCTCCCGCAAGGGAAACGCCGTACTCATGTCCGAGGAGGACTTCACGGCGTGGACGGAGACGGTGCACCTCCTGC
GCTCGCCCAAGAACGCCCGCCGTCTGCTCGACTCCATCGCGGAGGCCGAAGCGGGCGAAGCACGGCATCGCGAGCTGATC
GACCCGGACGCGGAGCGGGCGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9098.33 Da        Isoelectric Point: 5.6007

>AT195374 WP_003413183.1 NZ_CP071127:c2870356-2870111 [Mycobacterium tuberculosis]
MLVAYICHVKRLQIYIDEDVDRALAVEARRRRTSKAALIREYVAEHLRQPGPDPVDAFVGSFVGEADLSASVDDVVYGKH
E

Download         Length: 246 bp

>AT195374 NZ_CP094676:6467882-6468136 [Streptomyces sp. CB09030]
GTGAGGGTCACTTTCACGTCCCACGGCTGGGAGGACTACGTCCACTGGGCCGAGAGCGACCGGAAGGTGACCAAGCGGAT
CAACAGACTGATCGACGACATCACCCGTGACCCGTTCAAGGGCATCGGGAAGCCGGAGCCGCTCAAGGGCGACCTGTCGG
GCTACTGGTCACGGCGCATCGACGACACGCACCGGCTCGTGTACAAGCCCGCCGACGGCGTACTGGTCATCGTGCAGGCC
CGCTACCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5WZ4
PDB 5WZF

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BW31

References