Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2402189..2402718 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag JY387_RS11155 Protein ID WP_003411124.1
Coordinates 2402189..2402506 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag JY387_RS11160 Protein ID WP_003411127.1
Coordinates 2402503..2402718 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS11125 2397326..2398402 + 1077 WP_003411110.1 hypothetical protein -
JY387_RS11130 2398399..2398680 + 282 WP_003411112.1 hypothetical protein -
JY387_RS11135 2398716..2399789 + 1074 WP_206281270.1 quinone-dependent dihydroorotate dehydrogenase -
JY387_RS11140 2399794..2400324 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
JY387_RS11145 2400372..2401718 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
JY387_RS11155 2402189..2402506 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JY387_RS11160 2402503..2402718 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
JY387_RS11165 2402973..2404031 + 1059 WP_206337897.1 hypothetical protein -
JY387_RS11170 2404161..2404517 - 357 WP_003411130.1 hypothetical protein -
JY387_RS11175 2404612..2405394 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
JY387_RS11180 2405662..2405952 - 291 WP_003900476.1 YggT family protein -
JY387_RS11185 2406114..2406770 - 657 WP_206280207.1 cell division protein SepF -
JY387_RS11190 2406839..2407612 - 774 Protein_2212 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T195369 WP_003411124.1 NZ_CP071127:c2402506-2402189 [Mycobacterium tuberculosis]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T195369 NZ_CP094663:c1982689-1982423 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT195369 WP_003411127.1 NZ_CP071127:c2402718-2402503 [Mycobacterium tuberculosis]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT195369 NZ_CP094663:c1982946-1982689 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References