195368

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2364082..2364777 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag JY387_RS10950 Protein ID WP_206280200.1
Coordinates 2364082..2364516 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag JY387_RS10955 Protein ID WP_003410814.1
Coordinates 2364523..2364777 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS10940 2360236..2363277 + 3042 WP_206280198.1 DEAD/DEAH box helicase -
JY387_RS10945 2363270..2364103 + 834 WP_206280199.1 SWIM zinc finger family protein -
JY387_RS10950 2364082..2364516 - 435 WP_206280200.1 PIN domain-containing protein Toxin
JY387_RS10955 2364523..2364777 - 255 WP_003410814.1 antitoxin Antitoxin
JY387_RS10960 2364793..2365050 - 258 WP_003410816.1 hypothetical protein -
JY387_RS10965 2365461..2366722 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
JY387_RS10970 2367355..2367651 + 297 WP_003410820.1 PE family protein -
JY387_RS10975 2367707..2368438 + 732 WP_003900467.1 PPE family protein -
JY387_RS10980 2368979..2369725 - 747 WP_206280201.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15648.05 Da        Isoelectric Point: 7.4681

>T195368 WP_206280200.1 NZ_CP071127:c2364516-2364082 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTSSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T195368 NZ_CP094663:c1951405-1951298 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT195368 WP_003410814.1 NZ_CP071127:c2364777-2364523 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT195368 NZ_CP094663:1951221-1951281 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References