195361

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2203677..2204221 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name parE Uniprot ID G0TLU9
Locus tag JY387_RS10195 Protein ID WP_003409896.1
Coordinates 2203677..2203973 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P67299
Locus tag JY387_RS10200 Protein ID WP_003409899.1
Coordinates 2203970..2204221 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS10140 2198710..2199060 - 351 WP_206281223.1 hypothetical protein -
JY387_RS10145 2199071..2199973 - 903 WP_206338254.1 hypothetical protein -
JY387_RS10150 2199994..2200185 - 192 WP_003409876.1 hypothetical protein -
JY387_RS10155 2200186..2200482 - 297 WP_003409877.1 hypothetical protein -
JY387_RS10160 2200722..2200937 + 216 WP_003409878.1 antitoxin -
JY387_RS10165 2200934..2201245 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
JY387_RS10170 2201219..2201740 - 522 WP_003904745.1 hypothetical protein -
JY387_RS10175 2201715..2202092 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB -
JY387_RS10180 2202134..2202583 + 450 WP_206281224.1 helix-turn-helix domain-containing protein -
JY387_RS10185 2202580..2203125 + 546 WP_003409891.1 SecB-like chaperone -
JY387_RS10190 2203014..2203628 - 615 WP_003901296.1 hypothetical protein -
JY387_RS10195 2203677..2203973 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JY387_RS10200 2203970..2204221 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
JY387_RS10205 2204208..2204702 + 495 WP_003899099.1 hypothetical protein -
JY387_RS10210 2204862..2205269 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
JY387_RS10215 2205273..2205545 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JY387_RS10220 2205578..2206798 - 1221 WP_206338255.1 TetR family transcriptional regulator -
JY387_RS10225 2207696..2208493 + 798 WP_003899101.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-93)

Antitoxin

Antitoxin ParD

(2-80)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11268.64 Da        Isoelectric Point: 6.8604

>T195361 WP_003409896.1 NZ_CP071127:c2203973-2203677 [Mycobacterium tuberculosis]
VSSRYLLSPAAQAHLEEIWDCTYDRWGVDQAEQYLRELQHAIDRAAANPRIGRACDEIRPGYRKLSAGSHTLFYRVTGEG
TIDVVRVLHQRMDVDRNL

Download         Length: 297 bp

>T195361 NZ_CP094663:1340691-1340786 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9207.17 Da        Isoelectric Point: 7.0150

>AT195361 WP_003409899.1 NZ_CP071127:c2204221-2203970 [Mycobacterium tuberculosis]
VGKNTSFVLDEHYSAFIDGEIAAGRYRSASEVIRSALRLLEDRETQLRALREALEAGERSGSSTPFDFDGFLGRKRADAS
RGR

Download         Length: 252 bp

>AT195361 NZ_CP094663:c1340871-1340814 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TLU9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BUZ2

References