Detailed information of TA system TA195358

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1967701..1968161
• Replicon: chromosome
• Accession: NZ_CP071127
• Organism: Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TKL9
• Locus tag: JY387_RS09100
• Protein ID: WP_003898996.1
• Coordinates: 1967913..1968161 (+)
• Length: 83 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: JY387_RS09095
• Protein ID: WP_206338228.1
• Coordinates: 1967701..1967913 (+)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY387_RS09080	1964179..1965366	-	1188	WP_003898992.1	nitrate transporter NarK	-
JY387_RS09085	1965653..1965937	+	285	WP_206338266.1	DUF1876 domain-containing protein	-
JY387_RS09090	1965951..1967633	-	1683	WP_206338227.1	sulfate permease	-
JY387_RS09095	1967701..1967913	+	213	WP_206338228.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JY387_RS09100	1967913..1968161	+	249	WP_003898996.1	type II toxin-antitoxin system VapC family toxin	Toxin
JY387_RS09105	1968169..1968906	+	738	WP_003898997.1	hypothetical protein	-
JY387_RS09110	1969000..1970700	+	1701	WP_003898998.1	serine/threonine protein kinase PknE	-
JY387_RS09115	1970985..1971386	-	402	WP_003408538.1	hypothetical protein	-
JY387_RS09120	1971376..1971987	-	612	WP_003898999.1	isopentenyl-diphosphate Delta-isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin VapB-like (2-69)

Sequences

Toxin

Protein

• Length: 83 a.a.
• Molecular weight: 8884.14 Da
• Isoelectric Point: 4.1074

>T195358 WP_003898996.1 NZ_CP071127:1967913-1968161 [Mycobacterium tuberculosis]
MVIDTSALVAMLNDEPEAQRFEIAVAADHVWLMSTASYPEMATVIETRFGEPGGREPKVSGQPLLYKGDDFACIDIRAVL
AG

Nucleotide

• Length: 249 bp

>T195358 NZ_CP094658:c2168280-2168053 [Bifidobacterium longum subsp. infantis]
ATGAAGAAGCTGGATCGTAATGTTGCCAAGAGAATCATCGCAAAGCTTAGGGAAATTTCACAGTTGGAAGATCCGAGAAG
CACCGGCAAGGCTCTTGCCGGTAATCTGGCAGGGCTGTGGCGTTACCGTGTCGGGGACTATCGTATCGTGTGCGATATAG
AGGATGAGGTTCTGCTGATTCTTGTGATTGATGTCGCGCACAGGAGCAAGGTGTACAAGCGTTGCTGA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7607.80 Da
• Isoelectric Point: 9.3146

>AT195358 WP_206338228.1 NZ_CP071127:1967701-1967913 [Mycobacterium tuberculosis]
MELAARMGETLTQAVVVAVREQLARRTGRTRSISLREELAAIGRRCAALPVLDTRAADTILGYDERGLPA

Nucleotide

• Length: 213 bp

>AT195358 NZ_CP094658:c2168446-2168306 [Bifidobacterium longum subsp. infantis]
ATGAACGAAGCCCTTACCGAATCGATCGATAGGTTGGAGTATGAATACGGCATTATGAAAAAGGTCGAGGATTGGCGTGC
CGGCAGACTCGAAACCGTGACGCTCGACGAGCTGGAGGAAAGCCTTGGCTTGGAGGATTGA

Structures

Toxin

• AlphaFold DB: G0TKL9