195357

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1947026..1947639 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA2
Locus tag JY387_RS08990 Protein ID WP_003408465.1
Coordinates 1947026..1947415 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ52
Locus tag JY387_RS08995 Protein ID WP_003408469.1
Coordinates 1947412..1947639 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS08960 1942655..1943569 + 915 WP_003898985.1 3-hydroxyacyl-CoA dehydrogenase family protein -
JY387_RS08965 1943572..1944402 + 831 WP_206281164.1 cyclase family protein -
JY387_RS08970 1944402..1944752 + 351 WP_003898986.1 cupin domain-containing protein -
JY387_RS08975 1944805..1945623 + 819 WP_003408456.1 3-keto-5-aminohexanoate cleavage protein -
JY387_RS08980 1945637..1946416 + 780 WP_003408460.1 IclR family transcriptional regulator -
JY387_RS08990 1947026..1947415 - 390 WP_003408465.1 PIN domain-containing protein Toxin
JY387_RS08995 1947412..1947639 - 228 WP_003408469.1 antitoxin Antitoxin
JY387_RS09000 1947857..1949338 + 1482 Protein_1775 carboxylase -
JY387_RS09005 1949338..1950585 + 1248 WP_206281166.1 serine hydrolase -
JY387_RS09010 1950628..1951047 - 420 WP_206281167.1 hypothetical protein -
JY387_RS09015 1951037..1951747 - 711 WP_003408486.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13817.98 Da        Isoelectric Point: 7.0612

>T195357 WP_003408465.1 NZ_CP071127:c1947415-1947026 [Mycobacterium tuberculosis]
VIVLDASAAVELMLTTPAGAAVARRLRGETVHAPAHFDVEVIGAIRQAVVRQLISDHEGLVVVVNFLSLPVRRWPLKPFT
QRAYQLRSTHTVADGAYVALAEGLGVPLITCDGRLAQSHGHNAEIELVA

Download         Length: 390 bp

>T195357 NZ_CP094658:1761862-1762116 [Bifidobacterium longum subsp. infantis]
ATGCTGCTCTGCTGGACCGATGACGCCTGGGCCGACTACCTGTACTGGCAGGCTCAGGACCGCAAGACCCTCAAGCGCGT
CAACACGCTCATCCGGGACATGCAGCGAACCCCGTTCGAAGGCATCGGCAAGCCCGAACCCCTCAAATGGGGCCTGTCCG
GCGCATGGTCGCGGCGTATCGATTCGGCCAACCGTATCATCTATACCGTCGCCGACGACAGGCTCTGCATCCTCTCCGCG
AAGGACCACTACTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8226.39 Da        Isoelectric Point: 4.3313

>AT195357 WP_003408469.1 NZ_CP071127:c1947639-1947412 [Mycobacterium tuberculosis]
MSAMVQIRNVPDELLHELKARAAAQRMSLSDFLLARLAEIAEEPALDDVLDRLAALPRRDLGASAAELVDEARSE

Download         Length: 228 bp

>AT195357 NZ_CP094658:1761596-1761862 [Bifidobacterium longum subsp. infantis]
ATGACACAAGCCGTGGGCTACAGCAATTTCAGGGCGAATCTCAAGACCTATATGCGCAAGGTCAACGAGGACGCCGACAC
CCTTCTCGTGACCAACGCGGACCCGGAGGACAACGTGGTCGTCATGAGCGCCGACGACTACGATTCGCTCATGGAGACGC
TGCGCGTCTACCAGAACCCGTATCTGAGCGACAAGGTGATGCGCGGCATGGCGCAGGTCCGGCAGGGCCAGGCGATGGCC
CACGACCTTGTCGAAGCGGGCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BUI9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAN9

References