Detailed information of TA system TA195356

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1764766..1765379
• Replicon: chromosome
• Accession: NZ_CP071127
• Organism: Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: P64880
• Locus tag: JY387_RS08175
• Protein ID: WP_003407786.1
• Coordinates: 1764975..1765379 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0E8UJ46
• Locus tag: JY387_RS08170
• Protein ID: WP_009935474.1
• Coordinates: 1764766..1764969 (+)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY387_RS08140	1760171..1760551	+	381	WP_206281132.1	fumarate reductase subunit C	-
JY387_RS08145	1760548..1760925	+	378	WP_003407771.1	fumarate reductase subunit FrdD	-
JY387_RS08150	1760993..1761601	+	609	WP_003407773.1	TetR/AcrR family transcriptional regulator	-
JY387_RS08155	1761785..1762933	+	1149	Protein_1608	MMPL family transporter	-
JY387_RS08160	1762943..1763389	+	447	WP_003407780.1	F420H(2)-dependent quinone reductase	-
JY387_RS08165	1763424..1764713	+	1290	WP_003407781.1	threonine ammonia-lyase	-
JY387_RS08170	1764766..1764969	+	204	WP_009935474.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
JY387_RS08175	1764975..1765379	+	405	WP_003407786.1	type II toxin-antitoxin system toxin ribonuclease VapC11	Toxin
JY387_RS08180	1765396..1767138	-	1743	WP_003407788.1	malto-oligosyltrehalose trehalohydrolase	-
JY387_RS08185	1767131..1769428	-	2298	WP_003407790.1	malto-oligosyltrehalose synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (2-44)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14650.76 Da
• Isoelectric Point: 5.6587

>T195356 WP_003407786.1 NZ_CP071127:1764975-1765379 [Mycobacterium tuberculosis]
MILIDTSAWVEYFRATGSIAAVEVRRLLSEEAARIAMCEPIAMEILSGALDDNTHTTLERLVNGLPSLNVDDAIDFRAAA
GIYRAARRAGETVRSINDCLIAALAIRHGARIVHRDADFDVIARITNLQAASFR

Nucleotide

• Length: 405 bp

>T195356 NZ_CP094658:1640786-1641109 [Bifidobacterium longum subsp. infantis]
ATGAAACGAGGTGAGATTCGGACGTTGCAGGCCGATGGCTACGCCAGCAAGCCACGGCCGGTTGTCATCGTGCAGAGCGA
TGCCGTCGATCGGTTCGATTCCGTCATCACTTGTCTGCTGACCTCATACGATTCCTCCGACATCGACACGCGGGTCCGAT
TGGAACCAAGTCCGGAGAACGGCCTGAACAAAGTGAGTTACGTGATGACGGACAAGATCGTCACCGTCGACCGCAAACTG
CTGGGATACCAAGTCGGCGTGGTTGATGATGCAGCCATGGCGAATATCGGCCGTCAGCTCATGCGGGTTCTAGGTTTGCT
GTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7501.48 Da
• Isoelectric Point: 4.3951

>AT195356 WP_009935474.1 NZ_CP071127:1764766-1764969 [Mycobacterium tuberculosis]
MSRTNIDIDDELAAEVMRRFGLTTKRAAVDLALRRLVGSPLSREFLLGLEGVGWEGDLDDLRSDRPD

Nucleotide

• Length: 204 bp

>AT195356 NZ_CP094658:1640560-1640799 [Bifidobacterium longum subsp. infantis]
ATGCAGATTGCCACGCGAGTTGATGACGAGCAGGCTGCGTTGTTTAAGGAGACGACCCGACAGCTGGGTACCACCCCGGC
CGATGCCCTGCGTATGTTCATCAGCGCGTTCAATGATTACCGTGGGTTCCCCTATGAGGTGCGTTTGCCACGAAATGACG
TGGAGCCGTTTGCGTCCGAGCGGGACGCTACTGAGTATGCCAGTCGTCTCGCCTTGAGGATGTCCGATGAAACGAGGTGA

Structures

Toxin

• PDB: 6A7V

Antitoxin

• AlphaFold DB: A0A0E8UJ46