195355

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1686267..1686883 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name mazF Uniprot ID G0TJ74
Locus tag JY387_RS07830 Protein ID WP_003407593.1
Coordinates 1686566..1686883 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TJ73
Locus tag JY387_RS07825 Protein ID WP_003900349.1
Coordinates 1686267..1686569 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS07815 1682153..1684000 + 1848 WP_003407585.1 methylmalonyl-CoA mutase small subunit -
JY387_RS07820 1684001..1686253 + 2253 WP_003407587.1 methylmalonyl-CoA mutase -
JY387_RS07825 1686267..1686569 + 303 WP_003900349.1 type II toxin-antitoxin system antitoxin MazE4 Antitoxin
JY387_RS07830 1686566..1686883 + 318 WP_003407593.1 type II toxin-antitoxin system toxin endoribonuclease MazF4 Toxin
JY387_RS07835 1686880..1687884 + 1005 WP_003407596.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
JY387_RS07840 1687937..1689226 + 1290 WP_206338203.1 serine hydrolase -
JY387_RS07845 1689299..1690072 - 774 WP_206281254.1 methyltransferase domain-containing protein -
JY387_RS07850 1690130..1690342 - 213 WP_003898900.1 dodecin family protein -
JY387_RS07855 1690352..1690576 - 225 WP_160522526.1 NUDIX domain-containing protein -
JY387_RS07860 1690846..1691874 + 1029 WP_003407612.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-99)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11377.97 Da        Isoelectric Point: 7.9950

>T195355 WP_003407593.1 NZ_CP071127:1686566-1686883 [Mycobacterium tuberculosis]
VNAPLRGQVYRCDLGYGAKPWLIVSNNARNRHTADVVAVRLTTTRRTIPTWVAMGPSDPLTGYVNADNIETLGKDELGDY
LGEVTPATMNKINTALATALGLPWP

Download         Length: 318 bp

>T195355 NZ_CP094658:1581060-1581416 [Bifidobacterium longum subsp. infantis]
ATGATGAAGACTGATCCGCGCCAGTTCGAGATATGGTGGGTGCCGTTCGCTTTTCCCGACAAGCCAGGCAAAGCGAAGAA
CCGTCCCAGCGTGATCCTCCAATGGGACGACGGCACCCGCATCGCCTTGGTGACCAAGGTCACCGGCAACACCTGGCGCG
ACGAACCGGGCTATGTGGTGCTGCGTGACTGGCAGGACGCGGGACTGAGCAAGCCCAGCGCCGTGCGATGCTCGCAACTG
CTGCGGCTGCCAAGCAATCTTTTCCTCGACGACGGCCCGACAGGAAGACTTTCGGCATATGATGCCGGCCGCGTCGCCTG
GGCGATCAACGAACTCTATCCGGGCCTACTAGCCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11173.42 Da        Isoelectric Point: 9.5564

>AT195355 WP_003900349.1 NZ_CP071127:1686267-1686569 [Mycobacterium tuberculosis]
VPFLVALSGIISGVRDHSMTVRLDQQTRQRLQDIVKGGYRSANAAIVDAINKRWEALHDEQLDAAYAAAIHDNPAYPYES
EAERSAARARRNARQQRSAQ

Download         Length: 303 bp

>AT195355 NZ_CP094658:1580777-1581073 [Bifidobacterium longum subsp. infantis]
ATGATGGCTATCAAGAAGAAGACCACAATCAGTCTGGATGCGCAGACCAAGCGTGACGGCATCGCCATACTTGACGCCAT
GGGGTTGAACCTGAGCACGTTTGCCGAAATGTCTCTCAGACAATTGGTACGCGACGGGCGTCTGCCATTCACGCCAAGCG
TCCGCCCTTCATTCGAAAAAGACAACGAGGGATATCCCCTGTTCAAAGCGAACATGGATGATCCCCGCATCGTGACGCCC
CAGATACGTGATGGTGCCGTGATCCTGCCGGAGGGTTGGGACGATGATGAAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5XE3
PDB 5XE2

Antitoxin

Source ID Structure
AlphaFold DB G0TJ73

References