195354

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 1574108..1574763 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name vapC Uniprot ID P9WFA6
Locus tag JY387_RS07320 Protein ID WP_003898861.1
Coordinates 1574108..1574509 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TIK2
Locus tag JY387_RS07325 Protein ID WP_003407272.1
Coordinates 1574506..1574763 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS07305 1569580..1570965 - 1386 WP_206281087.1 cytochrome P450 -
JY387_RS07310 1571043..1572077 + 1035 WP_003407264.1 AraC family transcriptional regulator -
JY387_RS07315 1572123..1573853 - 1731 WP_206338189.1 PE domain-containing protein -
JY387_RS07320 1574108..1574509 - 402 WP_003898861.1 type II toxin-antitoxin system VapC family toxin Toxin
JY387_RS07325 1574506..1574763 - 258 WP_003407272.1 ribbon-helix-helix domain-containing protein Antitoxin
JY387_RS07330 1574846..1575805 - 960 WP_206338190.1 alpha/beta hydrolase fold domain-containing protein -
JY387_RS07335 1575830..1576792 - 963 WP_206281089.1 alpha/beta hydrolase fold domain-containing protein -
JY387_RS07340 1576791..1577528 + 738 WP_031647000.1 lysoplasmalogenase -
JY387_RS07345 1577609..1579576 + 1968 WP_206338265.1 primosomal protein N' -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-108)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14952.43 Da        Isoelectric Point: 11.4656

>T195354 WP_003898861.1 NZ_CP071127:c1574509-1574108 [Mycobacterium tuberculosis]
MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRR
YRRSHNRIGLGDYLIAATADVQDLQLATLNVWHFPMFEQLKPPFAVPGHRPRA

Download         Length: 402 bp

>T195354 NZ_CP094658:c1518574-1518206 [Bifidobacterium longum subsp. infantis]
ATGACCAGTACGCCAAGTGAACCGCGCCTGTATGACGTGTGGCTGATGTGGGTCGAGTTTCCCGACCATCCCGGTATCGG
CAAGCCGCGTCCCGTGGTAATCACCGAGGTTGACGGTGATCTGGTGTCGGGTATCGTGGCGAAGATAACCGGCAACACTG
ATTGGGATGAGGCCGGCGACGTGCCGCTGCTCGACTGGAAAGCCGAGGGACTGGCGAAGCCGTCGCTCGTGCGCTGTTCG
CAACGCTTCTACTTCAACAGGAGCGAACTGCTGCAATGGTTCGGACGACTCTCGTTGAGGGACGCGGAGCATGTTAACGA
CGGATTGGAAGCCACGTTGGACATTCCACCATACAGGCGGAGCGTATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9443.58 Da        Isoelectric Point: 6.4631

>AT195354 WP_003407272.1 NZ_CP071127:c1574763-1574506 [Mycobacterium tuberculosis]
MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQV
WRATS

Download         Length: 258 bp

>AT195354 NZ_CP094658:c1518839-1518555 [Bifidobacterium longum subsp. infantis]
ATGGGTAAGCTGGTCGCCAATATTGATGATGATGTCAAGGCGCGTGCCGCCGCGCTCTACGATTCCATGGGCATGAGCCT
GAGCACCGCAGTCAACATGTTTTTACGCCAGTCTTTGGTGGACAACGGGTTGCCGTTCAAGCCGACGCGGCACACGCCTG
ACGGCTATCCGGTGCCGCCTGTTCACAATGCCTACATGTTCGAGCGTTCGGAGAAGGGCCATGTGATACTGCCCGCCGAT
TGGAATGATTCGGAGGATGATGTCTATGACCAGTACGCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045ISB0

Antitoxin

Source ID Structure
AlphaFold DB G0TIK2

References