195343

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-mazE/PIN(toxin)
Location 754979..755771 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name vapC Uniprot ID P9WFB2
Locus tag JY387_RS03465 Protein ID WP_003403386.1
Coordinates 755334..755771 (-) Length 146 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G0TQE0
Locus tag JY387_RS03460 Protein ID WP_003403381.1
Coordinates 754979..755224 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS03430 749999..751504 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
JY387_RS03435 751585..752595 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JY387_RS03440 752983..753366 - 384 WP_003403365.1 ribonuclease VapC6 -
JY387_RS03445 753461..753616 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin -
JY387_RS03450 753692..754408 - 717 WP_206280903.1 CPBP family intramembrane metalloprotease -
JY387_RS03455 754684..754992 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JY387_RS03460 754979..755224 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family Antitoxin
JY387_RS03465 755334..755771 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin Toxin
JY387_RS03470 755768..756022 - 255 WP_003911263.1 antitoxin VapB7 -
JY387_RS03475 756136..758499 + 2364 WP_206280904.1 sulfatase-like hydrolase/transferase -
JY387_RS03480 758562..758888 + 327 WP_003403401.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JY387_RS03485 758800..759138 + 339 WP_003403405.1 PIN domain-containing protein -
JY387_RS03490 759135..759308 + 174 WP_003898549.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 15245.39 Da        Isoelectric Point: 5.1865

>T195343 WP_003403386.1 NZ_CP071127:c755771-755334 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR

Download         Length: 438 bp

>T195343 NZ_CP094557:c44089-43142 [Acinetobacter sp. YH12068_T]
ATGCCTGATATAAAAAATGTGTTTGCAGATGTCGCTGATGCACTTGGTATTGGTGCAACTTCTATTGTTGAAAAAGATTA
CTATGTTGTCGAGTTATTGAGACTATTACAGTCTCTAGAATTTGAAACGCATGACTTGGTTTTTGCTGGTGGAACTTCTT
TAGCTAAAGCAAATATTCAGTTAAATCGGATGTCTGAAGATGTGGACATTAAAATAGTTCCAAAACCAAATATTGCATTA
AGTCGCTCTAAAGCTAAAGTTGTACGTAAACAATTGCTTCATCAAGTACAAGACAAAATCTCTCAATCTGATTTCTTTAC
AATTGAAGAGGAACCAGTTGTCTGGGATGAATATCGTTATATGGAATTATTAATTCGATATCCTCAGCATTTCAACCAAG
CTCCCTGTTTACGACCATTCATTAAATTGGAATTAGTTGAAACAGACTTACTTGAGCCTTTTGAATCTAGAAGTATCACC
TCGTTTGTGTATGACTTGGCTAAGAAAGGGAAGCCAGTCGATGCTTTTCCCTCCGTCACAATTGTCAGTACCAGTATCGA
GAAGCTGATAGCAATTTTAAGGCGTACAGCGGCCTTTGCTAGAAATGCTGAAAGAGCTGATGATGAATCATTAGTTCGAC
ATGTGTATGACTACTTTAAAATTACCTATGGTAAACCACAAGATTTTGTTTATTTAGGGCACTTAGCTACTAAAGTTATA
AAAACTGATATTGAGCGTTATGGTCGTCAGCATACTCTTATGGTTGAAGACCCGATTGCTGAATTGTTATTTGGTTTAAA
TGAATTAAGTCGTAATCCACTCTATAAAGCCAGGTTTAATAATTTTGTTGTTCCTATGGTGTTCGGGGACAAACAAATAT
CATGGCAGCAAGCCTATTCACATTTTCAGGACTCAGTTCAACAGATCTTCGCTAACTTAAAGTTGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9169.01 Da        Isoelectric Point: 4.2070

>AT195343 WP_003403381.1 NZ_CP071127:c755224-754979 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R

Download         Length: 246 bp

>AT195343 NZ_CP094557:c44477-44082 [Acinetobacter sp. YH12068_T]
ATGACAACTAAAGCGAAAATGCAAATGCGCATCAAACGCTCAAAACGTTATGTTTTTATGCGTGATGATTTTAATGACAT
TGCGAATTATGACCAAATTGGAAGAGTTCTGCGAAACTTAGTTCAAGAAGGTGAGCTAATTAAAGTTGGTTATGGTATTT
ATACCAAAGCAAGAAAAAATCAAATTACCGGCAAAGTAATGCCAGCCTGTCCAGAAGGCGCGGATGCAGTGATCTTAGAG
GCATTAAAAAGATTGGATGTGCAGGTTACGTTAGGAGAGGCTACGGAAAAATATTTATCTGGTCAATCCACCCAGATTCC
AGCCTTTACTCAAATTAAAACCCCGCGTCGTTTTACACGCCAATTGTCTGTAGGTCGTAGCCAAATTAATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSW5

Antitoxin

Source ID Structure
AlphaFold DB G0TQE0

References