195341

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 752983..753616 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name vapC Uniprot ID G0TQD6
Locus tag JY387_RS03440 Protein ID WP_003403365.1
Coordinates 752983..753366 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ56
Locus tag JY387_RS03445 Protein ID WP_003403368.1
Coordinates 753461..753616 (-) Length 52 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS03415 748275..748811 + 537 WP_003403341.1 50S ribosomal protein L10 -
JY387_RS03420 748848..749240 + 393 WP_003403353.1 50S ribosomal protein L7/L12 -
JY387_RS03425 749233..749928 - 696 WP_003403355.1 TetR/AcrR family transcriptional regulator -
JY387_RS03430 749999..751504 + 1506 WP_003403360.1 carotenoid cleavage oxygenase -
JY387_RS03435 751585..752595 + 1011 WP_003911248.1 ABC transporter ATP-binding protein -
JY387_RS03440 752983..753366 - 384 WP_003403365.1 ribonuclease VapC6 Toxin
JY387_RS03445 753461..753616 - 156 WP_003403368.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
JY387_RS03450 753692..754408 - 717 WP_206280903.1 CPBP family intramembrane metalloprotease -
JY387_RS03455 754684..754992 - 309 WP_003403376.1 type II toxin-antitoxin system PemK/MazF family toxin -
JY387_RS03460 754979..755224 - 246 WP_003403381.1 ribbon-helix-helix protein, CopG family -
JY387_RS03465 755334..755771 - 438 WP_003403386.1 type II toxin-antitoxin system VapC family toxin -
JY387_RS03470 755768..756022 - 255 WP_003911263.1 antitoxin VapB7 -
JY387_RS03475 756136..758499 + 2364 WP_206280904.1 sulfatase-like hydrolase/transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-44)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13959.73 Da        Isoelectric Point: 6.0803

>T195341 WP_003403365.1 NZ_CP071127:c753366-752983 [Mycobacterium tuberculosis]
MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVG
ALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD

Download         Length: 384 bp

>T195341 NZ_CP094555:456409-456795 [Acinetobacter sp. YH12068_T]
ATGGATAATCGGCAATTCAAACTGAAACGCAGTTTTTTATCGCATGCGTTTCAGTTTTTTATTTTTGCGGTATTGATGAC
GCTGCTTTATCAGTTACTAACGCCCATGCTTTGGGGGATATTTTTCCTAATCGGGCTAGTGGTTTATGTTCTGTTTTTCC
GTAAGCATTTACACGTCACCAGTCTAGAATATTTGGATGGAACTGATTGGTCTTTGCAACGACTGAACCGCCCGGTGCAA
CGCGTTCAAATTAGCCATATTTTGGATCATCAAATGTATATCGTGGTGTATTTTATGCATGCGCGTGCAAAACCGGTGAT
TATTTGGCGCGATCAATTGTCATTGAAACAGTGGAAATCACTCAAAGTATTGGCCAAAATGATCTAA

Antitoxin


Download         Length: 52 a.a.        Molecular weight: 5872.72 Da        Isoelectric Point: 5.7734

>AT195341 WP_003403368.1 NZ_CP071127:c753616-753461 [Mycobacterium tuberculosis]
VSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE

Download         Length: 156 bp

>AT195341 NZ_CP094555:456159-456416 [Acinetobacter sp. YH12068_T]
ATGACTGATGAAATCAGCTTAGAAGAGCGTAAAGTGATCTACCGTGCACGTCGTGGTTTAAAAGAGATTGATGTTTATTT
TGATCCCTACGTCAAAAATTACTATTTACAAGCCGATGCAGCTGAAAAAGACATGTTTGCAGAACTCGTTGCTGCAGAAG
ATCCAGATTTGTTGGATTGGTTTATGGAAGTTAGTGAACCGCCACGTCCTGAATTAAAAACGTTTATTCAAAAATTAAAA
CATTACGTTCATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQD6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSF8

References