195333

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 640227..640903 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag JY387_RS02865 Protein ID WP_003898500.1
Coordinates 640227..640640 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag JY387_RS02870 Protein ID WP_003402915.1
Coordinates 640637..640903 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS02835 635572..635874 - 303 WP_003402896.1 DUF3349 domain-containing protein -
JY387_RS02840 635934..636212 - 279 WP_003402901.1 hypothetical protein -
JY387_RS02845 636209..637462 - 1254 WP_206280883.1 inorganic phosphate transporter -
JY387_RS02850 637582..637968 - 387 WP_003402907.1 VOC family protein -
JY387_RS02855 638031..638915 - 885 WP_003402909.1 SDR family oxidoreductase -
JY387_RS02860 639011..639913 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
JY387_RS02865 640227..640640 - 414 WP_003898500.1 PIN domain-containing protein Toxin
JY387_RS02870 640637..640903 - 267 WP_003402915.1 antitoxin VapB3 Antitoxin
JY387_RS02875 641095..642810 - 1716 WP_206280884.1 fatty-acid--CoA ligase FadD8 -
JY387_RS02880 642888..644492 + 1605 WP_003402920.1 amidohydrolase -
JY387_RS02885 644489..645469 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T195333 WP_003898500.1 NZ_CP071127:c640640-640227 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T195333 NZ_CP094541:3388023-3388316 [Acinetobacter sp. YH16040_T]
ATGACTTATAAGCTTTTACGTCATAAGGACTTCACAGCTGAATGGGAAAAGCTTCCTAGTGCTATAAGAGATCAATTTAA
GAAAAAACTTGCCAAGGTCATAGAGCAGCCACATATTCCAAAGAATATGCTTAGAGGTGATCTTGCAGGTTGCTACAAAA
TTAAATTATTAAAGGCTGGAGTCCGACTAGTTTATCAAGTTAAAGATGATCAGGTAGTTATCTTGCTCATTACGGTTGGG
AAACGAGCTGACAGCATAGTTTATGACGAAGCGAAAAAGCGCATTAAAGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT195333 WP_003402915.1 NZ_CP071127:c640903-640637 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp

>AT195333 NZ_CP094541:3387788-3388033 [Acinetobacter sp. YH16040_T]
ATGGCTACTGTTAACTTCAGGGTCGATGAAGCCCTTAAAGAAAAATCTTATTCAGTTCTAAGAGAACAAGGTATTGCACC
TACTGAGTTTTTTACAAATGTCCTTGAATACATTGCAGCGACTGGGAAACTCCCTGTACAAAAAGCCTTACTCTCAGAAG
AGGATACCGAGCTATTAGCGATTGTTCGTAAACGTATTAATGATCCTAAAGAAATGTTTGAGGAAATTACTTTAGATGAC
TTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References