195332

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 444221..445232 Replicon chromosome
Accession NZ_CP071127
Organism Mycobacterium tuberculosis strain 120/26CAO

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag JY387_RS01910 Protein ID WP_003401859.1
Coordinates 444221..444814 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag JY387_RS01915 Protein ID WP_003401860.1
Coordinates 444843..445232 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY387_RS01890 439870..441252 + 1383 WP_003898415.1 magnesium transporter -
JY387_RS01895 441264..442298 - 1035 WP_206280824.1 class II fructose-bisphosphate aldolase -
JY387_RS01900 442394..443077 + 684 WP_003401857.1 VTT domain-containing protein -
JY387_RS01905 443066..444196 - 1131 WP_003401858.1 hypothetical protein -
JY387_RS01910 444221..444814 - 594 WP_003401859.1 zeta toxin family protein Toxin
JY387_RS01915 444843..445232 - 390 WP_003401860.1 hypothetical protein Antitoxin
JY387_RS01920 445313..446524 - 1212 WP_206338089.1 VWA domain-containing protein -
JY387_RS01925 446530..447132 - 603 WP_003898417.1 SRPBCC family protein -
JY387_RS01930 447146..448042 - 897 WP_206280828.1 AAA family ATPase -
JY387_RS01935 448039..448632 - 594 WP_003401864.1 NTP transferase domain-containing protein -
JY387_RS01940 448629..449384 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T195332 WP_003401859.1 NZ_CP071127:c444814-444221 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T195332 NZ_CP094541:c2934332-2933946 [Acinetobacter sp. YH16040_T]
ATGGATAATCGGCAATTCAAACTGAAACGCAGTTTTTTATCGCATGCGTTTCAGTTTTTTATTTTTGCGGTATTGATGAC
GCTGCTTTATCAGTTACTAACACCTATGCTTTGGGGGGTATTTTTCCTCATTGGACTAGTGGTTTATGTACTGTTTTTCC
GTAAGCATTTACACGTCACCAGTCTAGATTATTTGGATGGAACTGATTGGTCTTTGCAACGGCTCAACCGTCCAGTGCAA
CGCGTTCAAATTAGCCATATTTTGGATCATCAAATGTATATCGTGGTGTATTTTATGCATGCGCGTGCAAAACCAGTGAT
TATTTGGCGCGATCAATTGTCATTGAAACAGTGGAAATCACTCAAAGTATTGGCCAAAATGATCTAA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT195332 WP_003401860.1 NZ_CP071127:c445232-444843 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT195332 NZ_CP094541:c2934582-2934325 [Acinetobacter sp. YH16040_T]
ATGACTGATGAAATCAGCTTAGAAGAGCGTAAAGTGATCTACCGCGCACGTCGTGGTTTAAAAGAGATTGATGTTTATTT
TGATCCCTACGTCAAAAATTACTATTTACAAGCCGATGCAGCTGAAAAAGACATGTTTGCAGAACTCGTTGCTGCAGAAG
ATCCAGATTTGTTGGATTGGTTTATGGAAGTTAGTGAACCGCCACGTCCTGAATTAAAAACGTTTATTCAAAAATTAAAA
CATTACGTTCATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References