195324

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2030310..2030824 Replicon chromosome
Accession NZ_CP071104
Organism Staphylococcus aureus strain PS/BAC/317/16/W

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag JYA73_RS09760 Protein ID WP_000581791.1
Coordinates 2030310..2030519 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag JYA73_RS09765 Protein ID WP_000138934.1
Coordinates 2030531..2030824 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA73_RS09740 (JYA73_001950) 2025818..2027176 - 1359 WP_000611456.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
JYA73_RS09745 (JYA73_001951) 2027191..2028261 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
JYA73_RS09750 (JYA73_001952) 2028579..2029781 + 1203 WP_001631925.1 FtsW/RodA/SpoVE family cell cycle protein -
JYA73_RS09755 (JYA73_001953) 2030045..2030182 - 138 WP_000828354.1 Lmo0850 family protein -
JYA73_RS09760 (JYA73_001954) 2030310..2030519 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
JYA73_RS09765 (JYA73_001955) 2030531..2030824 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
JYA73_RS09770 (JYA73_001956) 2030990..2032474 + 1485 WP_208151397.1 cardiolipin synthase -
JYA73_RS09775 (JYA73_001957) 2032502..2033149 + 648 WP_001187612.1 HD domain-containing protein -
JYA73_RS09780 (JYA73_001958) 2033762..2034634 - 873 WP_000725802.1 membrane protein insertase YidC -
JYA73_RS09785 (JYA73_001959) 2034720..2035361 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T195324 WP_000581791.1 NZ_CP071104:c2030519-2030310 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T195324 NZ_CP094526:7843511-7843861 [Bradyrhizobium sp. ISRA464]
ATGAGACGCGGTGAGATCTGGACCGTCGCTGGCGGCAAGGATTACGCAGACAAGCCGCGCCCCGTCGTCATCGTGCAGGA
CGACAGGTTCGACGCGACCGACACCATCACCATTTGCGCCTTCACCACCGATCCGACGGATGCGCCGTTGTTCCGGCTCA
TCATCGAGCCGAATGAGCGCAACGGCTTGCTCTCGACATGCCGGCTGATGGTAGACAAAATCACAACCGTTCCCAAGGTC
AAGGTCGGCAGGCGTGTTGGGCGTCTCGACGACGAGAATATGGTACGGCTCAATCAGGCAATGATGGTGTTCCTCGGCAT
GGCCGTATCCCCCAGGGGCGGAAGAAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT195324 WP_000138934.1 NZ_CP071104:c2030824-2030531 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT195324 NZ_CP094526:7843290-7843514 [Bradyrhizobium sp. ISRA464]
ATGGCGACGGCATCAAGGCCCAAGCCTGGTCGGATGAAGGTGCGGGAACATCGTGAGAGGCTGCGGGCACAGGGCTTGCG
ACCTATCCAGATTTGGGTGCCCGACGTGCGGTCTTCATCCTTCCGCAAGCAGGCTCATCGTCAGTCACTTGCTGTTGCGG
CCAGCAGCCATGCGCGCGACGATCAGGCTTTCATCGACGACGTGTCCGACCTGGACGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References