Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2010565..2011094 Replicon chromosome
Accession NZ_CP071104
Organism Staphylococcus aureus strain PS/BAC/317/16/W

Toxin (Protein)


Gene name mazF Uniprot ID Q6GF05
Locus tag JYA73_RS09670 Protein ID WP_000621176.1
Coordinates 2010565..2010927 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag JYA73_RS09675 Protein ID WP_000948331.1
Coordinates 2010924..2011094 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA73_RS09650 (JYA73_001932) 2007544..2008314 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
JYA73_RS09655 (JYA73_001933) 2008289..2008768 - 480 WP_001190825.1 anti-sigma B factor RsbW -
JYA73_RS09660 (JYA73_001934) 2008770..2009096 - 327 WP_001052491.1 anti-sigma factor antagonist -
JYA73_RS09665 (JYA73_001935) 2009215..2010216 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
JYA73_RS09670 (JYA73_001936) 2010565..2010927 - 363 WP_000621176.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JYA73_RS09675 (JYA73_001937) 2010924..2011094 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
JYA73_RS09680 (JYA73_001938) 2011179..2012327 - 1149 WP_001281140.1 alanine racemase -
JYA73_RS09685 (JYA73_001939) 2012393..2012752 - 360 WP_000581197.1 holo-ACP synthase -
JYA73_RS09690 (JYA73_001940) 2012756..2013247 - 492 WP_001286801.1 PH domain-containing protein -
JYA73_RS09695 (JYA73_001941) 2013240..2014817 - 1578 WP_001294646.1 PH domain-containing protein -
JYA73_RS09700 (JYA73_001942) 2014810..2015289 - 480 WP_211021865.1 hypothetical protein -
JYA73_RS09705 (JYA73_001943) 2015499..2016059 - 561 WP_001092414.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13469.74 Da        Isoelectric Point: 10.1654

>T195323 WP_000621176.1 NZ_CP071104:c2010927-2010565 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVVHQKN

Download         Length: 363 bp

>T195323 NZ_CP094526:4702646-4703047 [Bradyrhizobium sp. ISRA464]
ATGCCCGGTGACTTCTTCGACACCAACGTGCTCGTCTACCTCGCGTCCGGCGATCCCTTGAAGGCCGATCGTGCAGAAGC
CGTGATTGCCCGCGGCGGCGCGATTAGCGTGCAGGTGCTCAACGAAGTCACCAACGTCGCGCGCCGCAAGATGCGGATGT
CATGGACGGAGACGCGCGCATTTCTGACGATCTTGCGCAATCTGCTGACCGTTCATCCCCTTACGCTGGAAAGCCACGAC
ACCGGCCTCGACTTGGCTGAACGCTACAGCCTGTCGACCTTCGACGCCATGATCGCGGGGTCCGCACTTCACGCCGGTTG
CGACAGGTTATGGTCTGAGGACATGCAGCACGGCCTCGTGCTCGACGGCAGCCTTCGGATCGCCAATCCGTTTCGGGCTT
AA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT195323 WP_000948331.1 NZ_CP071104:c2011094-2010924 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT195323 NZ_CP094526:4702426-4702656 [Bradyrhizobium sp. ISRA464]
ATGCAAGTCGCCAAATGGGGCAACAGCCTCGCGATCCGGCTTCCCGCGTCTGTGGTCGAAGCGCTCAAACTCAAGGAAGG
CGACGAGATCGAAATCCACGTCGCCGACGAGCGGAACTTCGGCGTCGCGCGCAAACCGGGGCGCGAGGAGTTACTGGCAC
GACTGCGCGCCTTTCGCGGACGCCTGCCGGCGGATTTCAAATTCGACCGGGACGAGGCAAATGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A168PYX0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References