195322

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1854052..1854828 Replicon chromosome
Accession NZ_CP071104
Organism Staphylococcus aureus strain PS/BAC/317/16/W

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag JYA73_RS08770 Protein ID WP_000031108.1
Coordinates 1854052..1854204 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag JYA73_RS08775 Protein ID WP_001251219.1
Coordinates 1854229..1854828 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA73_RS08755 (JYA73_001753) 1849674..1850495 + 822 WP_000669380.1 RluA family pseudouridine synthase -
JYA73_RS08760 (JYA73_001754) 1850951..1852336 - 1386 WP_000116227.1 class II fumarate hydratase -
JYA73_RS08765 (JYA73_001755) 1852532..1852927 - 396 WP_000901019.1 hypothetical protein -
JYA73_RS08770 (JYA73_001756) 1854052..1854204 - 153 WP_000031108.1 SAS053 family protein Toxin
JYA73_RS08775 (JYA73_001757) 1854229..1854828 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
JYA73_RS08780 (JYA73_001758) 1854987..1855457 - 471 WP_211021849.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
JYA73_RS08785 (JYA73_001759) 1855462..1856589 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
JYA73_RS08790 (JYA73_001760) 1856740..1857462 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
JYA73_RS08795 (JYA73_001761) 1857455..1858912 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hysA / lukD / hlgA 1795639..1857468 61829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T195322 WP_000031108.1 NZ_CP071104:c1854204-1854052 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T195322 NZ_CP094526:c3028082-3027894 [Bradyrhizobium sp. ISRA464]
ATGAGGTCGACGGACATCATCAAGGCCCTGCTGGCCGATGGTTGGAGACAGGTCACCCAGAAGGGTAGCCACGTTCAGTT
CAAACACCCAACCAAGCCGGGCCGCGTGACAGTCCCTCACCCGAAACGGGATATCCCTGTTGGGACCTTCAAGAGCATTG
AGAAGCAGTCCGGCCTGAAACTGAAATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT195322 WP_001251219.1 NZ_CP071104:c1854828-1854229 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT195322 NZ_CP094526:c3027849-3027457 [Bradyrhizobium sp. ISRA464]
ATGCGACACTACATTGCCCTGATCCATAAGGACGCCGACAGCGATTACGGCGTCTCGTTTCCCGATCTACCTGGCGTCAT
CACTGCGGGTACTGATCTGGACGACGCGCGCACGATGGCCGCGGAAGCCTTGGCCCTCCATCTAGAAGGTTTGGCCGAAG
ACGGTGAAGCCGTGCCTGAGCCTTCCTCTCTCGAGGAGATCATGGCCGATGTCGAAAATCGAGATGGCGTAGCCGTGCTC
ATTCCGGCCCCGTCGGAGGGCGTGAAGAGTGTTCGTGTCAACATCACTCTTCCGTCCGACATACTCAACGAGATTGATCG
TCGTGCCGAACAAGAGGGATTCACTCGCTCGGGCTTTCTCGCTCAGGCTGCTAGGAAAGCGTTGACAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References