Detailed information of TA system TA195321

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 793741..794218
• Replicon: chromosome
• Accession: NZ_CP071104
• Organism: Staphylococcus aureus strain PS/BAC/317/16/W

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: JYA73_RS03715
• Protein ID: WP_000052076.1
• Coordinates: 793741..793929 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: JYA73_RS03720
• Protein ID: WP_001059690.1
• Coordinates: 793958..794218 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA73_RS03685 (JYA73_000738)	789729..790251	+	523	Protein_717	hypothetical protein	-
JYA73_RS03690 (JYA73_000739)	790592..791278	+	687	WP_001574556.1	thermonuclease family protein	-
JYA73_RS03695 (JYA73_000740)	791635..791835	+	201	WP_001059082.1	cold-shock protein	-
JYA73_RS03700 (JYA73_000741)	792332..792550	-	219	WP_211022035.1	hypothetical protein	-
JYA73_RS03705 (JYA73_000742)	792612..792896	-	285	WP_001004395.1	hypothetical protein	-
JYA73_RS03710 (JYA73_000743)	792984..793553	-	570	WP_001106663.1	lipoprotein N-acylation protein LnsA	-
JYA73_RS03715 (JYA73_000744)	793741..793929	-	189	WP_000052076.1	hypothetical protein	Toxin
JYA73_RS03720 (JYA73_000745)	793958..794218	-	261	WP_001059690.1	hypothetical protein	Antitoxin
JYA73_RS03725 (JYA73_000746)	794559..794762	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
JYA73_RS03730 (JYA73_000747)	794759..794995	-	237	WP_000368687.1	hypothetical protein	-
JYA73_RS03735 (JYA73_000748)	795220..795801	+	582	WP_001140696.1	histidine phosphatase family protein	-
JYA73_RS03740 (JYA73_000749)	795874..796491	-	618	WP_000255545.1	LysE/ArgO family amino acid transporter	-
JYA73_RS03745 (JYA73_000750)	796646..797140	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
JYA73_RS03750 (JYA73_000751)	797539..797961	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
JYA73_RS03755 (JYA73_000752)	798109..798825	+	717	WP_000150036.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (10-56)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T195321 WP_000052076.1 NZ_CP071104:c793929-793741 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T195321 NZ_CP094526:c2977469-2977068 [Bradyrhizobium sp. ISRA464]
GTGACGCGCTACCTGCTCGACACCAACATCATTTCCGACCTCGTCAGAAATCCGCAAGGCAAGGTGGCGAAGCGGATCGC
AAAGGTTGGCGAGGCCAATGTCTGCACAAGCATCATTGTCGCGTCCGAACTGCGCTACGGCTGTGCGAAGGCCGGATCGC
CACGGCTCACCAAAGCCGTCGAGGAGATTCTTGGCGAGATCCCCGTGCTGCCCTTCGATGTTCCCGCCGACGCAGAATAC
GGGGTTGTCCGCTCAGAACTGGAAGCTGCCGGAAAGCCGATTGGTAGCAACGATCTCCTGATCGCTGCGCACGCCTCCGC
ATTGAGCATGACTATCGTGACCGCCAATACCGACGAGTTCAAACGAGCCCGTGGCTTAAAAGTCACCAACTGGCTTGATT
GA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT195321 WP_001059690.1 NZ_CP071104:c794218-793958 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT195321 NZ_CP094526:c2977702-2977466 [Bradyrhizobium sp. ISRA464]
ATGACCCAGCGGAGACACGTTAGGTTGTTCCGGAATGGCCGCAACCAGGCGGTCCGCATCCCCGTGGAATTCGAAATGCC
GGGCGATGAAGCGACCATGTTTCGCGACGGCGACAGGCTCGTGATCGAGCCGCTGCGTAAGCGCGGGCTTCTTGCCCTTC
TCAAAACGATGACGCCCGTTGCCGAGCATTTCCCGGAGATCGACGATCCTGCGCCGAAGCCGGAACGTGTGCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56