Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2623437..2623951 Replicon chromosome
Accession NZ_CP071102
Organism Staphylococcus aureus strain CI/BAC/25/13/W

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JYA70_RS12935 Protein ID WP_000581792.1
Coordinates 2623742..2623951 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JYA70_RS12930 Protein ID WP_000138932.1
Coordinates 2623437..2623730 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA70_RS12910 (2618908) 2618908..2619549 + 642 WP_000483153.1 thiamine phosphate synthase -
JYA70_RS12915 (2619635) 2619635..2620507 + 873 WP_000725802.1 membrane protein insertase YidC -
JYA70_RS12920 (2621112) 2621112..2621759 - 648 WP_001187630.1 HD domain-containing protein -
JYA70_RS12925 (2621787) 2621787..2623271 - 1485 WP_000571549.1 cardiolipin synthase -
JYA70_RS12930 (2623437) 2623437..2623730 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JYA70_RS12935 (2623742) 2623742..2623951 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JYA70_RS12940 (2624079) 2624079..2624216 + 138 WP_000828354.1 Lmo0850 family protein -
JYA70_RS12945 (2624480) 2624480..2625682 - 1203 WP_001109942.1 FtsW/RodA/SpoVE family cell cycle protein -
JYA70_RS12950 (2626000) 2626000..2627070 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JYA70_RS12955 (2627085) 2627085..2628443 + 1359 WP_211044213.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T195319 WP_000581792.1 NZ_CP071102:2623742-2623951 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T195319 NZ_CP094525:8304876-8305226 [Bradyrhizobium sp. ISRA463]
ATGAGACGCGGTGAGATCTGGACCGTCGCTGGCGGCAAGGATTACGCAGACAAGCCGCGCCCCGTCGTCATCGTGCAGGA
CGACAGGTTCGACGCGACCGACACCATCACCATTTGCGCCTTCACCACCGATCCGACGGATGCGCCGTTGTTCCGGCTCA
TCATCGAGCCGAATGAGCGCAACGGCTTGCTCTCGACATGCCGGCTGATGGTAGACAAAATCACAACCGTTCCCAAGGTC
AAGGTCGGCAGGCGTGTTGGGCGTCTCGACGACGAGAATATGGTACGGCTCAATCAGGCAATGATGGTGTTCCTCGGCAT
GGCCGTATCCCCCAGGGGCGGAAGAAAATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT195319 WP_000138932.1 NZ_CP071102:2623437-2623730 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT195319 NZ_CP094525:8304655-8304879 [Bradyrhizobium sp. ISRA463]
ATGGCGACGGCATCAAGGCCCAAGCCTGGTCGGATGAAGGTGCGGGAACATCGTGAGAGGCTGCGGGCACAGGGCTTGCG
ACCTATCCAGATTTGGGTGCCCGACGTGCGGTCTTCATCCTTCCGCAAGCAGGCTCATCGTCAGTCACTTGCTGTTGCGG
CCAGCAGCCATGCGCGCGACGATCAGGCTTTCATCGACGACGTGTCCGACCTGGACGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References