Detailed information of TA system TA195310

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1161962..1162439
• Replicon: chromosome
• Accession: NZ_CP071102
• Organism: Staphylococcus aureus strain CI/BAC/25/13/W

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: JYA70_RS05845
• Protein ID: WP_000052076.1
• Coordinates: 1162251..1162439 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: JYA70_RS05840
• Protein ID: WP_001059690.1
• Coordinates: 1161962..1162222 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA70_RS05805 (1157356)	1157356..1158072	-	717	WP_000150016.1	type I 3-dehydroquinate dehydratase	-
JYA70_RS05810 (1158220)	1158220..1158642	+	423	WP_000974448.1	organic hydroperoxide resistance protein	-
JYA70_RS05815 (1159041)	1159041..1159535	+	495	WP_000569884.1	GNAT family N-acetyltransferase	-
JYA70_RS05820 (1159690)	1159690..1160283	+	594	Protein_1122	LysE/ArgO family amino acid transporter	-
JYA70_RS05825 (1160379)	1160379..1160960	-	582	WP_001140696.1	histidine phosphatase family protein	-
JYA70_RS05830 (1161185)	1161185..1161421	+	237	WP_000368687.1	hypothetical protein	-
JYA70_RS05835 (1161418)	1161418..1161621	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
JYA70_RS05840 (1161962)	1161962..1162222	+	261	WP_001059690.1	hypothetical protein	Antitoxin
JYA70_RS05845 (1162251)	1162251..1162439	+	189	WP_000052076.1	hypothetical protein	Toxin
JYA70_RS05850 (1162628)	1162628..1163197	+	570	WP_001106651.1	lipoprotein N-acylation protein LnsA	-
JYA70_RS05855 (1163285)	1163285..1163569	+	285	WP_001004401.1	hypothetical protein	-
JYA70_RS05860 (1163631)	1163631..1163849	+	219	WP_000005886.1	hypothetical protein	-
JYA70_RS05865 (1164346)	1164346..1164546	-	201	WP_001059082.1	cold-shock protein	-
JYA70_RS05870 (1164904)	1164904..1165590	-	687	WP_001806958.1	thermonuclease family protein	-
JYA70_RS05875 (1165930)	1165930..1166412	-	483	WP_000824468.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	seb / vWbp	1135263..1179228	43965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T195310 WP_000052076.1 NZ_CP071102:1162251-1162439 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T195310 NZ_CP094521:c2713271-2713083 [Bradyrhizobium sp. ISRA437]
ATGAGGTCGACAGACCTCATCAAGGCCATGCTGGCCGATGGTTGGAGACAGGTCAGCCAGAAGGGTAGCCACGTTCAGTT
CAAACACCTAACCAAGCCCAGCCGCGTGACAGTCCCTCACCCGAAACGGGATATCCCTGTTGGGACCTTCAAGAGCATTG
AGAAGCAGTCCGGCCTGAAACTGAAATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT195310 WP_001059690.1 NZ_CP071102:1161962-1162222 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT195310 NZ_CP094521:c2713044-2712652 [Bradyrhizobium sp. ISRA437]
ATGCGACACTACATTGCCCTGATCCATAAGGACGCCGACAGCGATTACGGCGTCTCGTTTCCCGATCTACCTGGCGTCAT
CACTTCGGGTACCGATCTGGACGACGCGCGCACGATGGCCGCGGAAGCCTTGGCCCTCCATCTAGAAGGTTTGGCCGAAG
ACGGTGAAGCCGTGCCTGAGCCTTCCTCTCTCGAGAAGATCATGGCCGATGTCGAAAATCGAGATGGCGTAGCCGTGCTC
ATTCCGGCTCCGTCGGAGGGCGTGAAGAGTGTTCGTGTCAACATCACTCTTCCGTCCGACATACTCAACGAGATCGATCG
TCGTGCCGAACAAGAGGGATTCACTCGCTCGGGCTTTCTCGCTCAGGCTGCTAGGAAAGCTTTGGCAGCCTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56