Detailed information of TA system TA195307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 120595..121371
• Replicon: chromosome
• Accession: NZ_CP071102
• Organism: Staphylococcus aureus strain CI/BAC/25/13/W

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: JYA70_RS00775
• Protein ID: WP_000031108.1
• Coordinates: 121219..121371 (+)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: JYA70_RS00770
• Protein ID: WP_001251226.1
• Coordinates: 120595..121194 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA70_RS00750 (116511)	116511..117968	+	1458	WP_000649907.1	ABC transporter permease subunit	-
JYA70_RS00755 (117961)	117961..118683	+	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
JYA70_RS00760 (118834)	118834..119961	+	1128	WP_211044214.1	tRNA epoxyqueuosine(34) reductase QueG	-
JYA70_RS00765 (119966)	119966..120436	+	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
JYA70_RS00770 (120595)	120595..121194	+	600	WP_001251226.1	glucosamine-6-phosphate isomerase	Antitoxin
JYA70_RS00775 (121219)	121219..121371	+	153	WP_000031108.1	SAS053 family protein	Toxin
JYA70_RS00780 (122148)	122148..122543	+	396	WP_000901023.1	hypothetical protein	-
JYA70_RS00785 (122739)	122739..124124	+	1386	WP_000116231.1	class II fumarate hydratase	-
JYA70_RS00790 (124575)	124575..125396	-	822	WP_211044215.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T195307 WP_000031108.1 NZ_CP071102:121219-121371 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T195307 NZ_CP094519:c2714703-2714515 [Bradyrhizobium sp. ISRA436]
ATGAGGTCGACAGACCTCATCAAGGCCATGCTGGCCGATGGTTGGAGACAGGTCAGCCAGAAGGGTAGCCACGTTCAGTT
CAAACACCTAACCAAGCCCAGCCGCGTGACAGTCCCTCACCCGAAACGGGATATCCCTGTTGGGACCTTCAAGAGCATTG
AGAAGCAGTCCGGCCTGAAACTGAAATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22373.50 Da
• Isoelectric Point: 5.1445

>AT195307 WP_001251226.1 NZ_CP071102:120595-121194 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAATGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT195307 NZ_CP094519:c2714476-2714084 [Bradyrhizobium sp. ISRA436]
ATGCGACACTACATTGCCCTGATCCATAAGGACGCCGACAGCGATTACGGCGTCTCGTTTCCCGATCTACCTGGCGTCAT
CACTTCGGGTACCGATCTGGACGACGCGCGCACGATGGCCGCGGAAGCCTTGGCCCTCCATCTAGAAGGTTTGGCCGAAG
ACGGTGAAGCCGTGCCTGAGCCTTCCTCTCTCGAGAAGATCATGGCCGATGTCGAAAATCGAGATGGCGTAGCCGTGCTC
ATTCCGGCTCCGTCGGAGGGCGTGAAGAGTGTTCGTGTCAACATCACTCTTCCGTCCGACATACTCAACGAGATCGATCG
TCGTGCCGAACAAGAGGGATTCACTCGCTCGGGCTTTCTCGCTCAGGCTGCTAGGAAAGCTTTGGCAGCCTGA

Structures

Toxin

• AlphaFold DB: X5E2E6