Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2118903..2119417 Replicon chromosome
Accession NZ_CP071100
Organism Staphylococcus aureus strain PS/BAC/169/17/W

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag JYA66_RS10435 Protein ID WP_000581792.1
Coordinates 2118903..2119112 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag JYA66_RS10440 Protein ID WP_000138932.1
Coordinates 2119124..2119417 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA66_RS10415 (2114803) 2114803..2115873 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
JYA66_RS10420 (2116191) 2116191..2117393 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
JYA66_RS10425 (2117536) 2117536..2118226 - 691 Protein_2028 transposase -
JYA66_RS10430 (2118638) 2118638..2118775 - 138 WP_000828354.1 Lmo0850 family protein -
JYA66_RS10435 (2118903) 2118903..2119112 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
JYA66_RS10440 (2119124) 2119124..2119417 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
JYA66_RS10445 (2119583) 2119583..2121067 + 1485 WP_000571549.1 cardiolipin synthase -
JYA66_RS10450 (2121095) 2121095..2121742 + 648 WP_001187634.1 HD domain-containing protein -
JYA66_RS10455 (2122470) 2122470..2123342 - 873 WP_000725802.1 membrane protein insertase YidC -
JYA66_RS10460 (2123428) 2123428..2124069 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T195297 WP_000581792.1 NZ_CP071100:c2119112-2118903 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T195297 NZ_CP094512:1839735-1839837 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT195297 WP_000138932.1 NZ_CP071100:c2119417-2119124 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT195297 NZ_CP094512:c1839844-1839699 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References