Detailed information of TA system TA195289

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 835883..836360
• Replicon: chromosome
• Accession: NZ_CP071100
• Organism: Staphylococcus aureus strain PS/BAC/169/17/W

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: JYA66_RS03970
• Protein ID: WP_000052076.1
• Coordinates: 835883..836071 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: JYA66_RS03975
• Protein ID: WP_001059690.1
• Coordinates: 836100..836360 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JYA66_RS03940 (831874)	831874..832395	+	522	WP_042909090.1	hypothetical protein	-
JYA66_RS03945 (832736)	832736..833422	+	687	WP_001792695.1	thermonuclease family protein	-
JYA66_RS03950 (833779)	833779..833979	+	201	WP_001059082.1	cold-shock protein	-
JYA66_RS03955 (834474)	834474..834692	-	219	WP_000005884.1	hypothetical protein	-
JYA66_RS03960 (834754)	834754..835038	-	285	WP_001004394.1	hypothetical protein	-
JYA66_RS03965 (835126)	835126..835695	-	570	WP_001106652.1	lipoprotein N-acylation protein LnsA	-
JYA66_RS03970 (835883)	835883..836071	-	189	WP_000052076.1	hypothetical protein	Toxin
JYA66_RS03975 (836100)	836100..836360	-	261	WP_001059690.1	hypothetical protein	Antitoxin
JYA66_RS03980 (836701)	836701..836904	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
JYA66_RS03985 (836901)	836901..837137	-	237	WP_000368687.1	hypothetical protein	-
JYA66_RS03990 (837362)	837362..837943	+	582	WP_001140696.1	histidine phosphatase family protein	-
JYA66_RS03995 (838016)	838016..838633	-	618	WP_000255557.1	LysE/ArgO family amino acid transporter	-
JYA66_RS04000 (838788)	838788..839282	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
JYA66_RS04005 (839681)	839681..840103	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
JYA66_RS04010 (840251)	840251..840967	+	717	WP_000150013.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-112)

Antitoxin

• Predicted DNA-binding protein, ribbon-helix-helix domain (16-47)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T195289 WP_000052076.1 NZ_CP071100:c836071-835883 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T195289 NZ_CP094479:c5192898-5192515 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATTATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT195289 WP_001059690.1 NZ_CP071100:c836360-836100 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT195289 NZ_CP094479:c5193140-5192898 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56