Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 835883..836360 Replicon chromosome
Accession NZ_CP071100
Organism Staphylococcus aureus strain PS/BAC/169/17/W

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag JYA66_RS03970 Protein ID WP_000052076.1
Coordinates 835883..836071 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag JYA66_RS03975 Protein ID WP_001059690.1
Coordinates 836100..836360 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JYA66_RS03940 (831874) 831874..832395 + 522 WP_042909090.1 hypothetical protein -
JYA66_RS03945 (832736) 832736..833422 + 687 WP_001792695.1 thermonuclease family protein -
JYA66_RS03950 (833779) 833779..833979 + 201 WP_001059082.1 cold-shock protein -
JYA66_RS03955 (834474) 834474..834692 - 219 WP_000005884.1 hypothetical protein -
JYA66_RS03960 (834754) 834754..835038 - 285 WP_001004394.1 hypothetical protein -
JYA66_RS03965 (835126) 835126..835695 - 570 WP_001106652.1 lipoprotein N-acylation protein LnsA -
JYA66_RS03970 (835883) 835883..836071 - 189 WP_000052076.1 hypothetical protein Toxin
JYA66_RS03975 (836100) 836100..836360 - 261 WP_001059690.1 hypothetical protein Antitoxin
JYA66_RS03980 (836701) 836701..836904 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
JYA66_RS03985 (836901) 836901..837137 - 237 WP_000368687.1 hypothetical protein -
JYA66_RS03990 (837362) 837362..837943 + 582 WP_001140696.1 histidine phosphatase family protein -
JYA66_RS03995 (838016) 838016..838633 - 618 WP_000255557.1 LysE/ArgO family amino acid transporter -
JYA66_RS04000 (838788) 838788..839282 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
JYA66_RS04005 (839681) 839681..840103 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
JYA66_RS04010 (840251) 840251..840967 + 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T195289 WP_000052076.1 NZ_CP071100:c836071-835883 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T195289 NZ_CP094479:c5192898-5192515 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATTATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT195289 WP_001059690.1 NZ_CP071100:c836360-836100 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT195289 NZ_CP094479:c5193140-5192898 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References