Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2386883..2387394 Replicon chromosome
Accession NZ_CP071099
Organism Fusobacterium animalis strain THCT5A4

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag JY401_RS11330 Protein ID WP_220308193.1
Coordinates 2387140..2387394 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID F7L0U9
Locus tag JY401_RS11325 Protein ID WP_005910514.1
Coordinates 2386883..2387140 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY401_RS11305 (JY401_11300) 2382012..2384108 + 2097 WP_023038391.1 outer membrane protein assembly factor -
JY401_RS11310 (JY401_11305) 2384149..2384622 + 474 WP_005910511.1 OmpH family outer membrane protein -
JY401_RS11315 (JY401_11310) 2384650..2385648 + 999 WP_158411210.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
JY401_RS11320 (JY401_11315) 2385687..2386763 + 1077 WP_220308192.1 glycerophosphodiester phosphodiesterase -
JY401_RS11325 (JY401_11320) 2386883..2387140 + 258 WP_005910514.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JY401_RS11330 (JY401_11325) 2387140..2387394 + 255 WP_220308193.1 Txe/YoeB family addiction module toxin Toxin
JY401_RS11335 (JY401_11330) 2387515..2388591 + 1077 WP_023038388.1 DHH family phosphoesterase -
JY401_RS11340 (JY401_11335) 2388823..2389560 + 738 WP_220308194.1 tRNA pseudouridine(38-40) synthase TruA -
JY401_RS11345 (JY401_11340) 2389701..2390276 + 576 WP_005910552.1 aminoacyl-tRNA hydrolase -
JY401_RS11350 (JY401_11345) 2390350..2391666 + 1317 WP_005905476.1 electron transport complex subunit RsxC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10065.46 Da        Isoelectric Point: 7.1639

>T195288 WP_220308193.1 NZ_CP071099:2387140-2387394 [Fusobacterium animalis]
MLLTWTDFAWEQYEELQEKDKRLVKKINTLIKDIKRNDNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKISDTQITIVAC
ANHY

Download         Length: 255 bp

>T195288 NZ_CP094479:c4880573-4879656 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10140.41 Da        Isoelectric Point: 4.7022

>AT195288 WP_005910514.1 NZ_CP071099:2386883-2387140 [Fusobacterium animalis]
MIATNYSEVRNNLKTYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQRLVESIKEAEKGNVKEHD
LIEVD

Download         Length: 258 bp

>AT195288 NZ_CP094479:c4881337-4880579 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB F7L0U9

References