Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 666960..667471 Replicon chromosome
Accession NZ_CP071098
Organism Fusobacterium animalis strain THCT6B3

Toxin (Protein)


Gene name relB Uniprot ID F7L0U8
Locus tag JY403_RS03130 Protein ID WP_005910516.1
Coordinates 667217..667471 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID F7L0U9
Locus tag JY403_RS03125 Protein ID WP_005910514.1
Coordinates 666960..667217 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY403_RS03105 (JY403_03105) 662092..664185 + 2094 WP_220279876.1 outer membrane protein assembly factor -
JY403_RS03110 (JY403_03110) 664226..664699 + 474 WP_005910511.1 OmpH family outer membrane protein -
JY403_RS03115 (JY403_03115) 664727..665725 + 999 WP_158411210.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
JY403_RS03120 (JY403_03120) 665764..666840 + 1077 WP_220279877.1 glycerophosphodiester phosphodiesterase -
JY403_RS03125 (JY403_03125) 666960..667217 + 258 WP_005910514.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JY403_RS03130 (JY403_03130) 667217..667471 + 255 WP_005910516.1 Txe/YoeB family addiction module toxin Toxin
JY403_RS03135 (JY403_03135) 667592..668668 + 1077 WP_008798882.1 DHH family phosphoesterase -
JY403_RS03140 (JY403_03140) 668900..669637 + 738 WP_220279878.1 tRNA pseudouridine(38-40) synthase TruA -
JY403_RS03145 (JY403_03145) 669778..670353 + 576 WP_220279879.1 aminoacyl-tRNA hydrolase -
JY403_RS03150 (JY403_03150) 670427..671743 + 1317 WP_005905476.1 electron transport complex subunit RsxC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10007.42 Da        Isoelectric Point: 8.0154

>T195287 WP_005910516.1 NZ_CP071098:667217-667471 [Fusobacterium animalis]
MLLTWTDFAWEQYEELQEKDKRLVKKINTLIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKISDTQITIVAC
ANHY

Download         Length: 255 bp

>T195287 NZ_CP094479:c4720112-4719828 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10140.41 Da        Isoelectric Point: 4.7022

>AT195287 WP_005910514.1 NZ_CP071098:666960-667217 [Fusobacterium animalis]
MIATNYSEVRNNLKTYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQRLVESIKEAEKGNVKEHD
LIEVD

Download         Length: 258 bp

>AT195287 NZ_CP094479:c4720344-4720102 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F7L0U8

Antitoxin

Source ID Structure
AlphaFold DB F7L0U9

References