Detailed information of TA system TA195285

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 947223..947734
• Replicon: chromosome
• Accession: NZ_CP071097
• Organism: Fusobacterium animalis strain THCT7A2

Toxin (Protein)

• Gene name: relB
• Uniprot ID: F7L0U8
• Locus tag: JY398_RS04455
• Protein ID: WP_005910516.1
• Coordinates: 947480..947734 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: F7L0U9
• Locus tag: JY398_RS04450
• Protein ID: WP_005910514.1
• Coordinates: 947223..947480 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY398_RS04430 (JY398_04430)	942352..944448	+	2097	WP_220298248.1	outer membrane protein assembly factor	-
JY398_RS04435 (JY398_04435)	944489..944962	+	474	WP_005910511.1	OmpH family outer membrane protein	-
JY398_RS04440 (JY398_04440)	944990..945988	+	999	WP_220298249.1	UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase	-
JY398_RS04445 (JY398_04445)	946027..947103	+	1077	WP_008798881.1	glycerophosphodiester phosphodiesterase	-
JY398_RS04450 (JY398_04450)	947223..947480	+	258	WP_005910514.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
JY398_RS04455 (JY398_04455)	947480..947734	+	255	WP_005910516.1	Txe/YoeB family addiction module toxin	Toxin
JY398_RS04460 (JY398_04460)	947855..948931	+	1077	WP_008798882.1	DHH family phosphoesterase	-
JY398_RS04465 (JY398_04465)	949172..949909	+	738	WP_220298250.1	tRNA pseudouridine(38-40) synthase TruA	-
JY398_RS04470 (JY398_04470)	950050..950625	+	576	WP_220298251.1	aminoacyl-tRNA hydrolase	-
JY398_RS04475 (JY398_04475)	950699..952015	+	1317	WP_060675640.1	electron transport complex subunit RsxC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10007.42 Da
• Isoelectric Point: 8.0154

>T195285 WP_005910516.1 NZ_CP071097:947480-947734 [Fusobacterium animalis]
MLLTWTDFAWEQYEELQEKDKRLVKKINTLIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKISDTQITIVAC
ANHY

Nucleotide

• Length: 255 bp

>T195285 NZ_CP094479:c4606828-4606295 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTATTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10140.41 Da
• Isoelectric Point: 4.7022

>AT195285 WP_005910514.1 NZ_CP071097:947223-947480 [Fusobacterium animalis]
MIATNYSEVRNNLKTYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQRLVESIKEAEKGNVKEHD
LIEVD

Nucleotide

• Length: 258 bp

>AT195285 NZ_CP094479:c4607105-4606839 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• AlphaFold DB: F7L0U8

Antitoxin

• AlphaFold DB: F7L0U9