Detailed information of TA system TA195284

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 49587..50074
• Replicon: chromosome
• Accession: NZ_CP071097
• Organism: Fusobacterium animalis strain THCT7A2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U7T8D3
• Locus tag: JY398_RS00300
• Protein ID: WP_017144934.1
• Coordinates: 49805..50074 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: JY398_RS00295
• Protein ID: WP_022069162.1
• Coordinates: 49587..49808 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JY398_RS00265 (JY398_00265)	44999..47419	+	2421	WP_258876208.1	MobA/MobL family protein	-
JY398_RS00270 (JY398_00270)	47407..47928	+	522	WP_017144932.1	hypothetical protein	-
JY398_RS00275 (JY398_00275)	47918..48217	+	300	WP_017144933.1	hypothetical protein	-
JY398_RS00280 (JY398_00280)	48243..48581	+	339	WP_220297851.1	hypothetical protein	-
JY398_RS00285 (JY398_00285)	48708..48968	+	261	WP_023038247.1	hypothetical protein	-
JY398_RS00290 (JY398_00290)	49045..49524	+	480	WP_220297852.1	hypothetical protein	-
JY398_RS00295 (JY398_00295)	49587..49808	+	222	WP_022069162.1	DUF6290 family protein	Antitoxin
JY398_RS00300 (JY398_00300)	49805..50074	+	270	WP_017144934.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JY398_RS00305 (JY398_00305)	50237..50557	+	321	WP_023038249.1	TrbC/VirB2 family protein	-
JY398_RS00310 (JY398_00310)	50571..51275	+	705	WP_005906936.1	type IV secretion system protein	-
JY398_RS00315 (JY398_00315)	51287..52123	+	837	WP_005908641.1	TrbG/VirB9 family P-type conjugative transfer protein	-
JY398_RS00320 (JY398_00320)	52133..53338	+	1206	WP_220297853.1	TrbI/VirB10 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	16251..62723	46472

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10523.14 Da
• Isoelectric Point: 9.4833

>T195284 WP_017144934.1 NZ_CP071097:49805-50074 [Fusobacterium animalis]
MTYTVNTTPQFDKEFKKLDKFTQKILATWIDKNLEGCENPRIQGKGLTSNRSGQWRYRIGDYRLICIIEDKELIILALTV
GHRRDVYEK

Nucleotide

• Length: 270 bp

>T195284 NZ_CP094479:3994133-3994351 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8381.67 Da
• Isoelectric Point: 6.3780

>AT195284 WP_022069162.1 NZ_CP071097:49587-49808 [Fusobacterium animalis]
MAFSIRLTEEEKKLATSYAKLNSLSLGEAFKKALFEKIEEEYDIVVAEESFKKYIDSGKKSRPFSELKKELGL

Nucleotide

• Length: 222 bp

>AT195284 NZ_CP094479:3993732-3994106 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAGGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: U7T8D3