Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 2211486..2212000 Replicon chromosome
Accession NZ_CP071096
Organism Fusobacterium polymorphum strain THCT7E2

Toxin (Protein)


Gene name relB Uniprot ID A0A0S2ZR73
Locus tag JY402_RS10600 Protein ID WP_060496756.1
Coordinates 2211486..2211743 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID U7TQU0
Locus tag JY402_RS10605 Protein ID WP_005919458.1
Coordinates 2211743..2212000 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JY402_RS10580 (JY402_10580) 2207194..2208501 - 1308 WP_220282986.1 electron transport complex subunit RsxC -
JY402_RS10585 (JY402_10585) 2208576..2209151 - 576 WP_220282987.1 aminoacyl-tRNA hydrolase -
JY402_RS10590 (JY402_10590) 2209362..2210099 - 738 WP_125200542.1 tRNA pseudouridine(38-40) synthase TruA -
JY402_RS10595 (JY402_10595) 2210293..2211369 - 1077 WP_220282988.1 DHH family phosphoesterase -
JY402_RS10600 (JY402_10600) 2211486..2211743 - 258 WP_060496756.1 Txe/YoeB family addiction module toxin Toxin
JY402_RS10605 (JY402_10605) 2211743..2212000 - 258 WP_005919458.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JY402_RS10610 (JY402_10610) 2212127..2213194 - 1068 WP_005901428.1 glycerophosphodiester phosphodiesterase -
JY402_RS10615 (JY402_10615) 2213238..2214236 - 999 WP_220282989.1 UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase -
JY402_RS10620 (JY402_10620) 2214262..2214735 - 474 WP_220282990.1 OmpH family outer membrane protein -
JY402_RS10625 (JY402_10625) 2214775..2216868 - 2094 WP_220282991.1 outer membrane protein assembly factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10160.65 Da        Isoelectric Point: 8.8765

>T195283 WP_060496756.1 NZ_CP071096:c2211743-2211486 [Fusobacterium polymorphum]
MLLTWTDFAWEQYEELQEKDKRLIKKINILIKDIKRNGNEGIGKPEPLQHELSGYWSRRIDDKNRLVYKVSDNQITIVAC
ANHYK

Download         Length: 258 bp

>T195283 NZ_CP094479:c3810583-3810266 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACTCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10110.43 Da        Isoelectric Point: 4.7022

>AT195283 WP_005919458.1 NZ_CP071096:c2212000-2211743 [Fusobacterium polymorphum]
MIATNYSEVRNNLKAYCDKATKDYETIIITRKNNENVVLMSEEEYNNLMENLYIRSNLKYYQKLVESIKEVEKGNVKEHD
LIEVD

Download         Length: 258 bp

>AT195283 NZ_CP094479:c3810273-3809986 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S2ZR73

Antitoxin

Source ID Structure
AlphaFold DB A0A0S2ZLE4

References